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Acute response to 7-day therapy with CPAP in patients with moderate to severe obstructive sleep apnea and cardiac arrhytmia
INTRODUCTION: Obstructive Sleep Apnea (OSA) has been associated with an elevated risk of cardiac arrhythmia. Continuous positive airway pressure (CPAP) is the selected treatment for moderate to severe OSA and could improve arrhythmias in the long term. However, the acute effect of CPAP has not been...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Association of Sleep and Latin American Federation of
Sleep
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916577/ https://www.ncbi.nlm.nih.gov/pubmed/29796202 http://dx.doi.org/10.5935/1984-0063.20180011 |
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author | Campos, Jerónimo Ernst, Glenda Blanco, Magali Cassano, Alejandra Tello-Santa-Cruz, Iván Cáceres-Monié, Cesar Muyran, Alexys Cansonieri, Romina Salvado, Alejandro Borsini, Eduardo |
author_facet | Campos, Jerónimo Ernst, Glenda Blanco, Magali Cassano, Alejandra Tello-Santa-Cruz, Iván Cáceres-Monié, Cesar Muyran, Alexys Cansonieri, Romina Salvado, Alejandro Borsini, Eduardo |
author_sort | Campos, Jerónimo |
collection | PubMed |
description | INTRODUCTION: Obstructive Sleep Apnea (OSA) has been associated with an elevated risk of cardiac arrhythmia. Continuous positive airway pressure (CPAP) is the selected treatment for moderate to severe OSA and could improve arrhythmias in the long term. However, the acute effect of CPAP has not been studied in detail. METHODS: We conducted a prospective study with 25 patients with moderate to severe OSA diagnosed by home respiratory polygraphy (RP) and arrhythmia and/or pauses in 24-hour Holter ECG. We analyzed inflammatory parameters and the rate of arrhythmias/pauses after 7 days of auto-adjusting CPAP. RESULTS: 92.5% of the patients were men with a mean age of 61.7±1.9 years. Body mass index (BMI) was 59.5±2.2 kg/m2, with a mean apnea hypopnea index (AHI) of 37.7±3.8 events/hour (ev/h), and a residual AHI (AHIr) of 5.3±0.53 ev/h. After short treatment with CPAP we observed a tendency to improvement in both the severity and number of ventricular extrasystoles (VE) (1595.0±850.3 vs. 926.4±434.5 respectively), pauses and the inflammatory parameters (CRP 3.9±3.1 vs. 1.7±1.2, glycemia 131.4±11.6 vs. 121.9±9.8, HOMA 24.4±3.1 vs. 21.7±2.8, insulin 7.6±1.4 vs. 7.2±1.2 (p>0.5). CONCLUSION: We didn't find significant changes in pauses, VE and inflammatory parameters with CPAP short therapy in CPAP naive patients recently diagnosed with OSA. |
format | Online Article Text |
id | pubmed-5916577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Brazilian Association of Sleep and Latin American Federation of
Sleep |
record_format | MEDLINE/PubMed |
spelling | pubmed-59165772018-05-24 Acute response to 7-day therapy with CPAP in patients with moderate to severe obstructive sleep apnea and cardiac arrhytmia Campos, Jerónimo Ernst, Glenda Blanco, Magali Cassano, Alejandra Tello-Santa-Cruz, Iván Cáceres-Monié, Cesar Muyran, Alexys Cansonieri, Romina Salvado, Alejandro Borsini, Eduardo Sleep Sci Original Article INTRODUCTION: Obstructive Sleep Apnea (OSA) has been associated with an elevated risk of cardiac arrhythmia. Continuous positive airway pressure (CPAP) is the selected treatment for moderate to severe OSA and could improve arrhythmias in the long term. However, the acute effect of CPAP has not been studied in detail. METHODS: We conducted a prospective study with 25 patients with moderate to severe OSA diagnosed by home respiratory polygraphy (RP) and arrhythmia and/or pauses in 24-hour Holter ECG. We analyzed inflammatory parameters and the rate of arrhythmias/pauses after 7 days of auto-adjusting CPAP. RESULTS: 92.5% of the patients were men with a mean age of 61.7±1.9 years. Body mass index (BMI) was 59.5±2.2 kg/m2, with a mean apnea hypopnea index (AHI) of 37.7±3.8 events/hour (ev/h), and a residual AHI (AHIr) of 5.3±0.53 ev/h. After short treatment with CPAP we observed a tendency to improvement in both the severity and number of ventricular extrasystoles (VE) (1595.0±850.3 vs. 926.4±434.5 respectively), pauses and the inflammatory parameters (CRP 3.9±3.1 vs. 1.7±1.2, glycemia 131.4±11.6 vs. 121.9±9.8, HOMA 24.4±3.1 vs. 21.7±2.8, insulin 7.6±1.4 vs. 7.2±1.2 (p>0.5). CONCLUSION: We didn't find significant changes in pauses, VE and inflammatory parameters with CPAP short therapy in CPAP naive patients recently diagnosed with OSA. Brazilian Association of Sleep and Latin American Federation of Sleep 2018 /pmc/articles/PMC5916577/ /pubmed/29796202 http://dx.doi.org/10.5935/1984-0063.20180011 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Original Article Campos, Jerónimo Ernst, Glenda Blanco, Magali Cassano, Alejandra Tello-Santa-Cruz, Iván Cáceres-Monié, Cesar Muyran, Alexys Cansonieri, Romina Salvado, Alejandro Borsini, Eduardo Acute response to 7-day therapy with CPAP in patients with moderate to severe obstructive sleep apnea and cardiac arrhytmia |
title | Acute response to 7-day therapy with CPAP in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
title_full | Acute response to 7-day therapy with CPAP in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
title_fullStr | Acute response to 7-day therapy with CPAP in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
title_full_unstemmed | Acute response to 7-day therapy with CPAP in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
title_short | Acute response to 7-day therapy with CPAP in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
title_sort | acute response to 7-day therapy with cpap in patients with moderate
to severe obstructive sleep apnea and cardiac arrhytmia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916577/ https://www.ncbi.nlm.nih.gov/pubmed/29796202 http://dx.doi.org/10.5935/1984-0063.20180011 |
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