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Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis

Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients w...

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Autores principales: Gao, Jie, Cao, Zongxun, Feng, Shunyi, Song, Yangying, Bai, Wenjing, Zhao, Shumin, Zhang, Suli, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916698/
https://www.ncbi.nlm.nih.gov/pubmed/29668605
http://dx.doi.org/10.1097/MD.0000000000010430
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author Gao, Jie
Cao, Zongxun
Feng, Shunyi
Song, Yangying
Bai, Wenjing
Zhao, Shumin
Zhang, Suli
Li, Yong
author_facet Gao, Jie
Cao, Zongxun
Feng, Shunyi
Song, Yangying
Bai, Wenjing
Zhao, Shumin
Zhang, Suli
Li, Yong
author_sort Gao, Jie
collection PubMed
description Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients with mild PQ poisoning admitted to Cangzhou Central Hospital between January 2012 and August 2017. Patients were grouped according to short-term treatment (3 mg/kg/day MP for 3 days) or prolonged treatment (3 mg/kg/day MP for 3 days, followed by dosage reduction by half every 3 days, with treatment terminated when a dosage of 0.375 mg/kg/day was reached). Lung function was evaluated at 2 to 3 months after PQ exposure. The forced expiratory volume in 1 second (85.72 ± 4.93% vs 78.41 ± 4.58%; P < .001), forced vital capacity (81.98 ± 4.93% vs 77.85 ± 4.37%; P < .001), and diffusing capacity (84.27 ± 5.16% vs 76.21 ± 3.71%; P < .001) in the prolonged low-dose MP group were improved compared with those in the short-term MP group. Patients with mild PQ poisoning treated with prolonged low-dose MP had better lung function 2 to 3 months after PQ poisoning.
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spelling pubmed-59166982018-05-01 Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis Gao, Jie Cao, Zongxun Feng, Shunyi Song, Yangying Bai, Wenjing Zhao, Shumin Zhang, Suli Li, Yong Medicine (Baltimore) 7200 Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients with mild PQ poisoning admitted to Cangzhou Central Hospital between January 2012 and August 2017. Patients were grouped according to short-term treatment (3 mg/kg/day MP for 3 days) or prolonged treatment (3 mg/kg/day MP for 3 days, followed by dosage reduction by half every 3 days, with treatment terminated when a dosage of 0.375 mg/kg/day was reached). Lung function was evaluated at 2 to 3 months after PQ exposure. The forced expiratory volume in 1 second (85.72 ± 4.93% vs 78.41 ± 4.58%; P < .001), forced vital capacity (81.98 ± 4.93% vs 77.85 ± 4.37%; P < .001), and diffusing capacity (84.27 ± 5.16% vs 76.21 ± 3.71%; P < .001) in the prolonged low-dose MP group were improved compared with those in the short-term MP group. Patients with mild PQ poisoning treated with prolonged low-dose MP had better lung function 2 to 3 months after PQ poisoning. Wolters Kluwer Health 2018-04-20 /pmc/articles/PMC5916698/ /pubmed/29668605 http://dx.doi.org/10.1097/MD.0000000000010430 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-sa/4.0 This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0
spellingShingle 7200
Gao, Jie
Cao, Zongxun
Feng, Shunyi
Song, Yangying
Bai, Wenjing
Zhao, Shumin
Zhang, Suli
Li, Yong
Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title_full Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title_fullStr Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title_full_unstemmed Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title_short Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis
title_sort patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: a retrospective analysis
topic 7200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916698/
https://www.ncbi.nlm.nih.gov/pubmed/29668605
http://dx.doi.org/10.1097/MD.0000000000010430
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