Cargando…
Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONC...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916712/ https://www.ncbi.nlm.nih.gov/pubmed/29668637 http://dx.doi.org/10.1097/MD.0000000000010515 |
_version_ | 1783317066412982272 |
---|---|
author | Li, Yanhong Wang, Zhongming Zhao, Yi Luo, Yubin Xu, Wangdong Marion, Tony N. Liu, Yi |
author_facet | Li, Yanhong Wang, Zhongming Zhao, Yi Luo, Yubin Xu, Wangdong Marion, Tony N. Liu, Yi |
author_sort | Li, Yanhong |
collection | PubMed |
description | RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking. DIAGNOSES: Based upon the patient's clinical feature and positive pathergy test , BD was confirmed. INTERVENTIONS: Conventional immunosuppressive therapy and anti-tumor necrosis factor inhibitors, adalimumab and etanercept, had no demonstrable clinical effect. Mesenchymal stem cell (MSC) injection combined with low-dose prednisone and thalidomide, however, completely ameliorated the ulcers on one leg, significantly improved ulcers on the other leg, and returned normal function to both legs. OUTCOMES: The ulcerative lesions remained in remission, and the affected leg functioned normally after 34 months’ follow-up. LESSONS: Our experience suggests that MSC infusion might be a potentially successful therapy for intractable drug-resistant BD patients with concomitant leg ulcer. |
format | Online Article Text |
id | pubmed-5916712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59167122018-05-01 Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review Li, Yanhong Wang, Zhongming Zhao, Yi Luo, Yubin Xu, Wangdong Marion, Tony N. Liu, Yi Medicine (Baltimore) 6900 RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking. DIAGNOSES: Based upon the patient's clinical feature and positive pathergy test , BD was confirmed. INTERVENTIONS: Conventional immunosuppressive therapy and anti-tumor necrosis factor inhibitors, adalimumab and etanercept, had no demonstrable clinical effect. Mesenchymal stem cell (MSC) injection combined with low-dose prednisone and thalidomide, however, completely ameliorated the ulcers on one leg, significantly improved ulcers on the other leg, and returned normal function to both legs. OUTCOMES: The ulcerative lesions remained in remission, and the affected leg functioned normally after 34 months’ follow-up. LESSONS: Our experience suggests that MSC infusion might be a potentially successful therapy for intractable drug-resistant BD patients with concomitant leg ulcer. Wolters Kluwer Health 2018-04-20 /pmc/articles/PMC5916712/ /pubmed/29668637 http://dx.doi.org/10.1097/MD.0000000000010515 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6900 Li, Yanhong Wang, Zhongming Zhao, Yi Luo, Yubin Xu, Wangdong Marion, Tony N. Liu, Yi Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title | Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title_full | Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title_fullStr | Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title_full_unstemmed | Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title_short | Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review |
title_sort | successful mesenchymal stem cell treatment of leg ulcers complicated by behcet disease: a case report and literature review |
topic | 6900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916712/ https://www.ncbi.nlm.nih.gov/pubmed/29668637 http://dx.doi.org/10.1097/MD.0000000000010515 |
work_keys_str_mv | AT liyanhong successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT wangzhongming successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT zhaoyi successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT luoyubin successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT xuwangdong successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT mariontonyn successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview AT liuyi successfulmesenchymalstemcelltreatmentoflegulcerscomplicatedbybehcetdiseaseacasereportandliteraturereview |