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The role of SeDeM for characterizing the active substance and polyvinyilpyrrolidone eliminating metastable forms in an oral lyophilizate—A preformulation study

A preformulation study of an oral lyophilisate with cetirizine dihydrochloride (CTZ) as active ingredient, mannitol and PVP K30 as bulking agents is presented. CTZ shown a humidity content of 0.150% and a spontaneous hygroscopicity of 0.200% (both determined by SeDeM diagram), demonstrating an adequ...

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Detalles Bibliográficos
Autores principales:	Flórez Borges, Paloma, García-Montoya, Encarna, Pérez-Lozano, Pilar, Jo, Enric, Miñarro, Montserrat, Manich, Albert, Suñé-Negre, Josep Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916852/ https://www.ncbi.nlm.nih.gov/pubmed/29689061 http://dx.doi.org/10.1371/journal.pone.0196049

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