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Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat

Belonging to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are interesting therapeutic tools for the treatment of various cardiovascular pathologies. The drugs are supposed to preferentially stimulate oxidized or heme-depleted, but not native sGC. Sinc...

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Detalles Bibliográficos
Autores principales:	Kollau, Alexander, Opelt, Marissa, Wölkart, Gerald, Gorren, Antonius C. F., Russwurm, Michael, Koesling, Doris, Mayer, Bernd, Schrammel, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916872/ https://www.ncbi.nlm.nih.gov/pubmed/29138269 http://dx.doi.org/10.1124/mol.117.109918

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