Cargando…

Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial

BACKGROUND/OBJECTIVES: There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate the effect of a lifestyle education intervention alone (LEI) or with...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaiyasoot, Kusuma, Sarasak, Rungnapha, Pheungruang, Banchamaphon, Dawilai, Suwitcha, Pramyothin, Pornpoj, Boonyasiri, Adhiratha, Supapueng, Orawan, Jassil, Friedrich C., Yamwong, Preyanuj, Batterham, Rachel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916885/
https://www.ncbi.nlm.nih.gov/pubmed/29695706
http://dx.doi.org/10.1038/s41387-018-0034-0
_version_ 1783317082489749504
author Chaiyasoot, Kusuma
Sarasak, Rungnapha
Pheungruang, Banchamaphon
Dawilai, Suwitcha
Pramyothin, Pornpoj
Boonyasiri, Adhiratha
Supapueng, Orawan
Jassil, Friedrich C.
Yamwong, Preyanuj
Batterham, Rachel L.
author_facet Chaiyasoot, Kusuma
Sarasak, Rungnapha
Pheungruang, Banchamaphon
Dawilai, Suwitcha
Pramyothin, Pornpoj
Boonyasiri, Adhiratha
Supapueng, Orawan
Jassil, Friedrich C.
Yamwong, Preyanuj
Batterham, Rachel L.
author_sort Chaiyasoot, Kusuma
collection PubMed
description BACKGROUND/OBJECTIVES: There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate the effect of a lifestyle education intervention alone (LEI) or with partial MR (LEI + MR) in obese Thai adults with MS. SUBJECTS/METHODS: A total of 110 patients were randomised to receive either LEI or LEI + MR. Both groups received LEI to achieve weight loss. LEI + MR group additionally received two MR daily to replace either breakfast, lunch or dinner. Mean ± SE body mass index of all participants was 34.6 ± 0.6 kg/m(2), mean ± SE age was 42.5 ± 1.1 years and 83% of patients were female. Both groups were compared for anthropometric and cardiometabolic indices at 12-week. Body weight was also compared at weeks 38 and 64. RESULTS: At 12 weeks, both groups exhibited statistically significant percentage weight loss (%WL) compared to initial weight but greater %WL was observed in LEI + MR compared to LEI, 2.9% vs. 1.5%, respectively (p < 0.05). MS criteria such as waist circumference and blood pressure improved significantly in both groups compared to baseline. However, improvement in fasting plasma glucose (FPG) was only significant in LEI + MR, and more participants with impaired FPG at baseline in LEI + MR (42.9%) than LEI (19%) returned to normal FPG at 12 weeks (p < 0.05). HbA(1c), fasting insulin and HOMA-IR in LEI + MR were significantly lower than with LEI. At the end of the 12-week intervention period, 16% of participants no longer fulfilled MS criteria. A statistically significant weight loss from baseline persisted until 38 weeks but no longer reached statistically significant difference between groups CONCLUSIONS: LEI and LEI + MR were acceptable and led to improvement in weight and MS. LEI + MR group exhibited additional weight reduction and glycemic benefits at 12 weeks.
format Online
Article
Text
id pubmed-5916885
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-59168852018-04-27 Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial Chaiyasoot, Kusuma Sarasak, Rungnapha Pheungruang, Banchamaphon Dawilai, Suwitcha Pramyothin, Pornpoj Boonyasiri, Adhiratha Supapueng, Orawan Jassil, Friedrich C. Yamwong, Preyanuj Batterham, Rachel L. Nutr Diabetes Article BACKGROUND/OBJECTIVES: There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate the effect of a lifestyle education intervention alone (LEI) or with partial MR (LEI + MR) in obese Thai adults with MS. SUBJECTS/METHODS: A total of 110 patients were randomised to receive either LEI or LEI + MR. Both groups received LEI to achieve weight loss. LEI + MR group additionally received two MR daily to replace either breakfast, lunch or dinner. Mean ± SE body mass index of all participants was 34.6 ± 0.6 kg/m(2), mean ± SE age was 42.5 ± 1.1 years and 83% of patients were female. Both groups were compared for anthropometric and cardiometabolic indices at 12-week. Body weight was also compared at weeks 38 and 64. RESULTS: At 12 weeks, both groups exhibited statistically significant percentage weight loss (%WL) compared to initial weight but greater %WL was observed in LEI + MR compared to LEI, 2.9% vs. 1.5%, respectively (p < 0.05). MS criteria such as waist circumference and blood pressure improved significantly in both groups compared to baseline. However, improvement in fasting plasma glucose (FPG) was only significant in LEI + MR, and more participants with impaired FPG at baseline in LEI + MR (42.9%) than LEI (19%) returned to normal FPG at 12 weeks (p < 0.05). HbA(1c), fasting insulin and HOMA-IR in LEI + MR were significantly lower than with LEI. At the end of the 12-week intervention period, 16% of participants no longer fulfilled MS criteria. A statistically significant weight loss from baseline persisted until 38 weeks but no longer reached statistically significant difference between groups CONCLUSIONS: LEI and LEI + MR were acceptable and led to improvement in weight and MS. LEI + MR group exhibited additional weight reduction and glycemic benefits at 12 weeks. Nature Publishing Group UK 2018-04-25 /pmc/articles/PMC5916885/ /pubmed/29695706 http://dx.doi.org/10.1038/s41387-018-0034-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chaiyasoot, Kusuma
Sarasak, Rungnapha
Pheungruang, Banchamaphon
Dawilai, Suwitcha
Pramyothin, Pornpoj
Boonyasiri, Adhiratha
Supapueng, Orawan
Jassil, Friedrich C.
Yamwong, Preyanuj
Batterham, Rachel L.
Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title_full Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title_fullStr Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title_full_unstemmed Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title_short Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
title_sort evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in thai adults with obesity and metabolic syndrome: a randomised trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916885/
https://www.ncbi.nlm.nih.gov/pubmed/29695706
http://dx.doi.org/10.1038/s41387-018-0034-0
work_keys_str_mv AT chaiyasootkusuma evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT sarasakrungnapha evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT pheungruangbanchamaphon evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT dawilaisuwitcha evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT pramyothinpornpoj evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT boonyasiriadhiratha evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT supapuengorawan evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT jassilfriedrichc evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT yamwongpreyanuj evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial
AT batterhamrachell evaluationofa12weeklifestyleeducationinterventionwithorwithoutpartialmealreplacementinthaiadultswithobesityandmetabolicsyndromearandomisedtrial