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Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) plays an important role in the formation of NADPH, which is critical for the maintenance of mitochondrial redox balance. Cis-diamminedichloroplatinum II (cisplatin), an effective anticancer drug, induces oxidative stress-related nephrot...

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Detalles Bibliográficos
Autores principales:	Kong, Min Jung, Han, Sang Jun, Kim, Jee In, Park, Jeen-Woo, Park, Kwon Moo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916920/ https://www.ncbi.nlm.nih.gov/pubmed/29695796 http://dx.doi.org/10.1038/s41419-018-0537-6

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