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Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction
BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother’s dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the m...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916951/ https://www.ncbi.nlm.nih.gov/pubmed/29695710 http://dx.doi.org/10.1038/s41387-018-0027-z |
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author | Monks, Jenifer Orlicky, David J. Stefanski, Adrianne L. Libby, Andrew E. Bales, Elise S. Rudolph, Michael C. Johnson, Ginger C. Sherk, Vanessa D. Jackman, Matthew R. Williamson, Kayla Carlson, Nichole E. MacLean, Paul S. McManaman, James L. |
author_facet | Monks, Jenifer Orlicky, David J. Stefanski, Adrianne L. Libby, Andrew E. Bales, Elise S. Rudolph, Michael C. Johnson, Ginger C. Sherk, Vanessa D. Jackman, Matthew R. Williamson, Kayla Carlson, Nichole E. MacLean, Paul S. McManaman, James L. |
author_sort | Monks, Jenifer |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother’s dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the mother’s diet and adiposity have long-term effects on the baby’s metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering. All pups were born to lean dams fed a low fat diet but were fostered onto lean or obese dams fed a high fat diet. This study design allowed us to discern the effects of a poor diet from those of mother’s adiposity and metabolism. The weaned offspring were placed on a high fat diet to test their metabolic function. RESULTS: In this feeding challenge, all male (but not female) offspring developed metabolic dysfunction. We saw increased weight gain in the pups nursed on an obesity-resistant dam fed a high fat diet, and increased pathogenesis including liver steatosis and adipose tissue inflammation, when compared to pups nursed on either obesity-prone dams on a high fat diet or lean dams on a low fat diet. CONCLUSION: Exposure to maternal over-nutrition, through the milk, is sufficient to shape offspring health outcomes in a sex- and organ-specific manner, and milk from a mother who is obesity-prone may partially protect the offspring from the insult of a poor diet. |
format | Online Article Text |
id | pubmed-5916951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59169512018-04-27 Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction Monks, Jenifer Orlicky, David J. Stefanski, Adrianne L. Libby, Andrew E. Bales, Elise S. Rudolph, Michael C. Johnson, Ginger C. Sherk, Vanessa D. Jackman, Matthew R. Williamson, Kayla Carlson, Nichole E. MacLean, Paul S. McManaman, James L. Nutr Diabetes Article BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother’s dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the mother’s diet and adiposity have long-term effects on the baby’s metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering. All pups were born to lean dams fed a low fat diet but were fostered onto lean or obese dams fed a high fat diet. This study design allowed us to discern the effects of a poor diet from those of mother’s adiposity and metabolism. The weaned offspring were placed on a high fat diet to test their metabolic function. RESULTS: In this feeding challenge, all male (but not female) offspring developed metabolic dysfunction. We saw increased weight gain in the pups nursed on an obesity-resistant dam fed a high fat diet, and increased pathogenesis including liver steatosis and adipose tissue inflammation, when compared to pups nursed on either obesity-prone dams on a high fat diet or lean dams on a low fat diet. CONCLUSION: Exposure to maternal over-nutrition, through the milk, is sufficient to shape offspring health outcomes in a sex- and organ-specific manner, and milk from a mother who is obesity-prone may partially protect the offspring from the insult of a poor diet. Nature Publishing Group UK 2018-04-25 /pmc/articles/PMC5916951/ /pubmed/29695710 http://dx.doi.org/10.1038/s41387-018-0027-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Monks, Jenifer Orlicky, David J. Stefanski, Adrianne L. Libby, Andrew E. Bales, Elise S. Rudolph, Michael C. Johnson, Ginger C. Sherk, Vanessa D. Jackman, Matthew R. Williamson, Kayla Carlson, Nichole E. MacLean, Paul S. McManaman, James L. Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title | Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title_full | Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title_fullStr | Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title_full_unstemmed | Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title_short | Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
title_sort | maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916951/ https://www.ncbi.nlm.nih.gov/pubmed/29695710 http://dx.doi.org/10.1038/s41387-018-0027-z |
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