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Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In an in vitro analysis using an engineered AAV...

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Detalles Bibliográficos
Autores principales:	Pei, Xiaolei, Earley, Lauriel Freya, He, Yi, Chen, Xiaojing, Hall, Nikita Elexa, Samulski, Richard Jude, Li, Chengwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916967/ https://www.ncbi.nlm.nih.gov/pubmed/29725339 http://dx.doi.org/10.3389/fimmu.2018.00844

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