Cargando…
Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth
PURPOSE: Glutamine (Gln) is essential for the proliferation of most cancer cells, making it an appealing target for cancer therapy. However, the role of Gln in gastric cancer (GC) metabolism is unknown and Gln-targeted therapy against GC remains scarce. The aim of this study was to investigate the r...
Autores principales: | Ye, Jianxin, Huang, Qiang, Xu, Jie, Huang, Jinsheng, Wang, Jinzhou, Zhong, Wenjing, Chen, Wannan, Lin, Xinjian, Lin, Xu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916984/ https://www.ncbi.nlm.nih.gov/pubmed/29435734 http://dx.doi.org/10.1007/s00432-018-2605-9 |
Ejemplares similares
-
ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells
por: Luo, Yijun, et al.
Publicado: (2020) -
DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β‐catenin signaling pathway
por: Ye, Jianxin, et al.
Publicado: (2017) -
Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2
por: Garibsingh, Rachel-Ann A., et al.
Publicado: (2018) -
Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth
por: Chiu, Martina, et al.
Publicado: (2018) -
Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth
por: Issaq, Sameer H., et al.
Publicado: (2019)