The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression

Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138(+) plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expressi...

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Detalles Bibliográficos
Autores principales: Ali, Mina, Ajore, Ram, Wihlborg, Anna-Karin, Niroula, Abhishek, Swaminathan, Bhairavi, Johnsson, Ellinor, Stephens, Owen W, Morgan, Gareth, Meissner, Tobias, Turesson, Ingemar, Goldschmidt, Hartmut, Mellqvist, Ulf-Henrik, Gullberg, Urban, Hansson, Markus, Hemminki, Kari, Nahi, Hareth, Waage, Anders, Weinhold, Niels, Nilsson, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917026/
https://www.ncbi.nlm.nih.gov/pubmed/29695719
http://dx.doi.org/10.1038/s41467-018-04082-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917026/
https://www.ncbi.nlm.nih.gov/pubmed/29695719
http://dx.doi.org/10.1038/s41467-018-04082-2

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