Cargando…

Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed

Today's biomedicine builds on the conviction that biochemistry can explain the creation of the body, its anatomy and physiology. Unfortunately there are still deep mysteries strangely “fighting back” when we try to define and understand the organism and its creation in the ontogenesis as emergi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ventegodt, Søren, Hermansen, Tyge Dahl, Flensborg-Madsen, Trine, Nielsen, Maj Lyck, Clausen, Birgitte, Merrick, Joav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917124/
https://www.ncbi.nlm.nih.gov/pubmed/17072488
http://dx.doi.org/10.1100/tsw.2006.234
_version_ 1783317134495973376
author Ventegodt, Søren
Hermansen, Tyge Dahl
Flensborg-Madsen, Trine
Nielsen, Maj Lyck
Clausen, Birgitte
Merrick, Joav
author_facet Ventegodt, Søren
Hermansen, Tyge Dahl
Flensborg-Madsen, Trine
Nielsen, Maj Lyck
Clausen, Birgitte
Merrick, Joav
author_sort Ventegodt, Søren
collection PubMed
description Today's biomedicine builds on the conviction that biochemistry can explain the creation of the body, its anatomy and physiology. Unfortunately there are still deep mysteries strangely “fighting back” when we try to define and understand the organism and its creation in the ontogenesis as emerging from biochemistry. In analysing this from a theoretical perspective using a mathematical model focusing on the noise in complex chemical systems we argue that evolving biological structure cannot in principle be a product of chemistry. In this paper we go through the chemical gradient model and argue that this is not able to explain the ontogenesis. We discuss the used gradients as information carriers in chemical self-organizing systems and argue that by use of the “Turing structures” we are only able to modelling the mostly simple biological systems. The bio-chemical model is only able to model simple organization but not to explain the complexity of biological phenomena. We conclude that we seemingly have presented a formal proof (a NO-GO theorem) that the self-organizing chemical systems that are using chemical gradients are not able to explain complex biological matters as the ontogenesis. We need a fundamentally new, information-carrying principle to understand biological information and biological order.
format Online
Article
Text
id pubmed-5917124
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher TheScientificWorldJOURNAL
record_format MEDLINE/PubMed
spelling pubmed-59171242018-06-03 Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed Ventegodt, Søren Hermansen, Tyge Dahl Flensborg-Madsen, Trine Nielsen, Maj Lyck Clausen, Birgitte Merrick, Joav ScientificWorldJournal Review Article Today's biomedicine builds on the conviction that biochemistry can explain the creation of the body, its anatomy and physiology. Unfortunately there are still deep mysteries strangely “fighting back” when we try to define and understand the organism and its creation in the ontogenesis as emerging from biochemistry. In analysing this from a theoretical perspective using a mathematical model focusing on the noise in complex chemical systems we argue that evolving biological structure cannot in principle be a product of chemistry. In this paper we go through the chemical gradient model and argue that this is not able to explain the ontogenesis. We discuss the used gradients as information carriers in chemical self-organizing systems and argue that by use of the “Turing structures” we are only able to modelling the mostly simple biological systems. The bio-chemical model is only able to model simple organization but not to explain the complexity of biological phenomena. We conclude that we seemingly have presented a formal proof (a NO-GO theorem) that the self-organizing chemical systems that are using chemical gradients are not able to explain complex biological matters as the ontogenesis. We need a fundamentally new, information-carrying principle to understand biological information and biological order. TheScientificWorldJOURNAL 2006-10-23 /pmc/articles/PMC5917124/ /pubmed/17072488 http://dx.doi.org/10.1100/tsw.2006.234 Text en Copyright © 2006 Søren Ventegodt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ventegodt, Søren
Hermansen, Tyge Dahl
Flensborg-Madsen, Trine
Nielsen, Maj Lyck
Clausen, Birgitte
Merrick, Joav
Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title_full Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title_fullStr Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title_full_unstemmed Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title_short Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
title_sort human development v: biochemistry unable to explain the emergence of biological form (morphogenesis) and therefore a new principle as source of biological information is needed
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917124/
https://www.ncbi.nlm.nih.gov/pubmed/17072488
http://dx.doi.org/10.1100/tsw.2006.234
work_keys_str_mv AT ventegodtsøren humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded
AT hermansentygedahl humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded
AT flensborgmadsentrine humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded
AT nielsenmajlyck humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded
AT clausenbirgitte humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded
AT merrickjoav humandevelopmentvbiochemistryunabletoexplaintheemergenceofbiologicalformmorphogenesisandthereforeanewprincipleassourceofbiologicalinformationisneeded