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COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation
The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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TheScientificWorldJOURNAL
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917273/ https://www.ncbi.nlm.nih.gov/pubmed/16752007 http://dx.doi.org/10.1100/tsw.2006.122 |
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author | Wallace, John L. |
author_facet | Wallace, John L. |
author_sort | Wallace, John L. |
collection | PubMed |
description | The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associated with significant gastrointestinal injury, and with toxicity in the renal and cardiovascular systems. COX-2 is now recognized as a source of mediators that produce many beneficial and detrimental effects in the digestive system. In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX–2—derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed. |
format | Online Article Text |
id | pubmed-5917273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-59172732018-06-03 COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation Wallace, John L. ScientificWorldJournal Review Article The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associated with significant gastrointestinal injury, and with toxicity in the renal and cardiovascular systems. COX-2 is now recognized as a source of mediators that produce many beneficial and detrimental effects in the digestive system. In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX–2—derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed. TheScientificWorldJOURNAL 2006-05-25 /pmc/articles/PMC5917273/ /pubmed/16752007 http://dx.doi.org/10.1100/tsw.2006.122 Text en Copyright © 2006 John L. Wallace. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wallace, John L. COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title_full | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title_fullStr | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title_full_unstemmed | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title_short | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
title_sort | cox-2: a pivotal enzyme in mucosal protection and resolution of inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917273/ https://www.ncbi.nlm.nih.gov/pubmed/16752007 http://dx.doi.org/10.1100/tsw.2006.122 |
work_keys_str_mv | AT wallacejohnl cox2apivotalenzymeinmucosalprotectionandresolutionofinflammation |