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Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells

Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic m...

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Autor principal: Murrell, Adele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917277/
https://www.ncbi.nlm.nih.gov/pubmed/17205195
http://dx.doi.org/10.1100/tsw.2006.318
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author Murrell, Adele
author_facet Murrell, Adele
author_sort Murrell, Adele
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description Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia.
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spelling pubmed-59172772018-06-03 Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells Murrell, Adele ScientificWorldJournal Review Article Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia. TheScientificWorldJOURNAL 2006-05-26 /pmc/articles/PMC5917277/ /pubmed/17205195 http://dx.doi.org/10.1100/tsw.2006.318 Text en Copyright © 2006 Adele Murrell. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Murrell, Adele
Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title_full Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title_fullStr Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title_full_unstemmed Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title_short Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
title_sort genomic imprinting and cancer: from primordial germ cells to somatic cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917277/
https://www.ncbi.nlm.nih.gov/pubmed/17205195
http://dx.doi.org/10.1100/tsw.2006.318
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