Cargando…

Substrate Specificity of Cysteine Proteases Beyond the S(2) Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue migration and reproduction. In spite of similarities...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corvo, Ileana, Ferraro, Florencia, Merlino, Alicia, Zuberbühler, Kathrin, O'Donoghue, Anthony J., Pastro, Lucía, Pi-Denis, Natalia, Basika, Tatiana, Roche, Leda, McKerrow, James H., Craik, Charles S., Caffrey, Conor R., Tort, José F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917446/ https://www.ncbi.nlm.nih.gov/pubmed/29725596 http://dx.doi.org/10.3389/fmolb.2018.00040

Ejemplares similares

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica
por: Corvo, Ileana, et al.
Publicado: (2013)

Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach
por: Ferraro, Florencia, et al.
Publicado: (2016)

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica
por: Robinson, Mark W., et al.
Publicado: (2011)

Cathepsin L3 From Fasciola hepatica Induces NLRP3 Inflammasome Alternative Activation in Murine Dendritic Cells
por: Celias, Daiana Pamela, et al.
Publicado: (2019)

Evaluation of Gelatinolytic and Collagenolytic Activity of Fasciola hepatica Recombinant Cathepsin-L1
por: Mokhtarian, Kobra, et al.
Publicado: (2020)

Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
por: Cancela, Martín, et al.
Publicado: (2010)

Role of Fasciola hepatica Small RNAs in the Interaction With the Mammalian Host
por: Fontenla, Santiago, et al.
Publicado: (2022)

Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay : Detection for Fasciola hepatica by colloidal gold
por: Liu, Shaoxiong, et al.
Publicado: (2023)

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease
por: Lowther, Jonathan, et al.
Publicado: (2009)

Fasciola hepatica in UK horses
por: Howell, A. K., et al.
Publicado: (2019)

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans
por: Garcia-Campos, Andres, et al.
Publicado: (2016)

The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica
por: KIANIFARD, Leila, et al.
Publicado: (2020)

Gastric Pseudotumor due to Fasciola hepatica
por: Calixto-Aguilar, Lesly, et al.
Publicado: (2019)

Genetic diversity of Fasciola hepatica in Austria
por: Husch, Christian, et al.
Publicado: (2020)

The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ)
por: Barbour, Tara, et al.
Publicado: (2021)

Inmunodiagnóstico de parasitosis por fasciola hepática
por: Alfaro López, Martha Alicia
Publicado: (1987)

ABC transporters of the liver fluke Fasciola hepatica
por: Kudlacek, Oliver, et al.
Publicado: (2012)

Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches
por: Hernández Alvarez, Lilian, et al.
Publicado: (2015)

Correction: Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches
Publicado: (2015)

Development of Functional Genomic Tools in Trematodes: RNA Interference and Luciferase Reporter Gene Activity in Fasciola hepatica
por: Rinaldi, Gabriel, et al.
Publicado: (2008)

Complete mitochondrial genomes of the ‘intermediate form’ of Fasciola and Fasciola gigantica, and their comparison with F. hepatica
por: Liu, Guo-Hua, et al.
Publicado: (2014)

Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis
por: Lalor, Richard, et al.
Publicado: (2021)

Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives
por: Ferraro, Florencia, et al.
Publicado: (2019)

Effect of Fasciola hepatica proteins on the functioning of rat hepatocytes
por: Wesołowska, Agnieszka, et al.
Publicado: (2011)

ABC transporters of Fasciola hepatica as putative drug targets
por: El-Kasaby, Ali, et al.
Publicado: (2011)

Predicting Impacts of Climate Change on Fasciola hepatica Risk
por: Fox, Naomi J., et al.
Publicado: (2011)

Fasciola Hepatica Infection as a Cause of Severe Hypereosinophilia
por: Kaymak Cihan, Meriç, et al.
Publicado: (2013)

Fasciola hepatica in Some Buffaloes and Cattle by PCR and Microscopy
por: Ayaz, Sultan, et al.
Publicado: (2014)

On the Occurrence of the Common Fluke (Fasciola Hepatica) in the Human Subject
por: Wilson, Andrew
Publicado: (1879)

Transcriptome assembly dataset of anthelmintic response in Fasciola hepatica
por: Miranda-Miranda, Estefan, et al.
Publicado: (2021)

Molecular characterization of Fasciola hepatica in endemic regions of Colombia
por: Garcia-Corredor, Diego, et al.
Publicado: (2023)

Fasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development
por: Collett, Clare F., et al.
Publicado: (2022)

Pleiotropic alterations in gene expression in Latin American Fasciola hepatica isolates with different susceptibility to drugs
por: Radio, Santiago, et al.
Publicado: (2018)

Apparent Triclabendazole-Resistant Human Fasciola hepatica Infection, the Netherlands
por: Winkelhagen, Annemarie J.S., et al.
Publicado: (2012)

Estudio de Fasciola hepática (Linneo, 1758) en México
por: Soria Flores, Elsa Adriana
Publicado: (1996)

Fasciola hepatica IN BOVINES IN BRAZIL: DATA AVAILABILITY AND SPATIAL DISTRIBUTION
por: Bennema, Sita C., et al.
Publicado: (2014)

Fasciola hepatica expresses multiple α- and β-tubulin isotypes
por: Ryan, Louise A., et al.
Publicado: (2008)

Local adaptation of the trematode Fasciola hepatica to the snail Galba truncatula
por: Dreyfuss, G., et al.
Publicado: (2012)

Three Living Fasciola Hepatica in the Biliary Tract of a Woman
por: Niknam, Ramin, et al.
Publicado: (2015)

Ectopic Human Fasciola hepatica Infection by an Adult Worm in the Mesocolon
por: Kim, Ah Jin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hkvjunjh31rgjr0nq3krn6qv4c