A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat

A serially transplantable rat hepatocellular carcinoma (HCC) line was established. The primary spontaneous HCC which developed in a 506‐day‐old male hereditary hepatitis LEC rat was inoculated into young LEC rats. Only this HCC of 18 primary HCCs was successful in serial transplantation. The establi...

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Detalles Bibliográficos
Autores principales: Masuda, Ryuichi, Yoshida, Michihiro C., Sasaki, Motomichi, Dempo, Kimimaro, Mori, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917461/
https://www.ncbi.nlm.nih.gov/pubmed/3130360
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01584.x
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author Masuda, Ryuichi
Yoshida, Michihiro C.
Sasaki, Motomichi
Dempo, Kimimaro
Mori, Michio
author_facet Masuda, Ryuichi
Yoshida, Michihiro C.
Sasaki, Motomichi
Dempo, Kimimaro
Mori, Michio
author_sort Masuda, Ryuichi
collection PubMed
description A serially transplantable rat hepatocellular carcinoma (HCC) line was established. The primary spontaneous HCC which developed in a 506‐day‐old male hereditary hepatitis LEC rat was inoculated into young LEC rats. Only this HCC of 18 primary HCCs was successful in serial transplantation. The established cell line was histologically identical to the primary HCC showing a well‐differentiated type with a trabecular structure of tumorous hepatocytes. The characteristic of albumin production was maintained. Chromosome analysis revealed rather widely dispersed polyploid chromosome numbers with a modal value at 96. Every metaphase contained two to five unusually large marker chromosomes.
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spelling pubmed-59174612018-05-11 A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat Masuda, Ryuichi Yoshida, Michihiro C. Sasaki, Motomichi Dempo, Kimimaro Mori, Michio Jpn J Cancer Res Article A serially transplantable rat hepatocellular carcinoma (HCC) line was established. The primary spontaneous HCC which developed in a 506‐day‐old male hereditary hepatitis LEC rat was inoculated into young LEC rats. Only this HCC of 18 primary HCCs was successful in serial transplantation. The established cell line was histologically identical to the primary HCC showing a well‐differentiated type with a trabecular structure of tumorous hepatocytes. The characteristic of albumin production was maintained. Chromosome analysis revealed rather widely dispersed polyploid chromosome numbers with a modal value at 96. Every metaphase contained two to five unusually large marker chromosomes. Blackwell Publishing Ltd 1988-02 /pmc/articles/PMC5917461/ /pubmed/3130360 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01584.x Text en
spellingShingle Article
Masuda, Ryuichi
Yoshida, Michihiro C.
Sasaki, Motomichi
Dempo, Kimimaro
Mori, Michio
A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title_full A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title_fullStr A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title_full_unstemmed A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title_short A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat
title_sort transplantable cell line derived from spontaneous hepatocellular carcinoma of the hereditary hepatitis lec rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917461/
https://www.ncbi.nlm.nih.gov/pubmed/3130360
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01584.x
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