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Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica

Three hundred and ninety‐five four‐week‐old SPF female ddY mice were each exposed to 5 or 6 cercariae of Schistosoma japonicum (Japanese strain) on their shaved abdomens and were maintained in a conditioned clean environment and fed on sterilized food and water. Fecal examinations at 8 to 10 weeks p...

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Detalles Bibliográficos
Autores principales: Amano, Teruaki, Oshima, Tomoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917462/
https://www.ncbi.nlm.nih.gov/pubmed/3130351
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01574.x
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author Amano, Teruaki
Oshima, Tomoo
author_facet Amano, Teruaki
Oshima, Tomoo
author_sort Amano, Teruaki
collection PubMed
description Three hundred and ninety‐five four‐week‐old SPF female ddY mice were each exposed to 5 or 6 cercariae of Schistosoma japonicum (Japanese strain) on their shaved abdomens and were maintained in a conditioned clean environment and fed on sterilized food and water. Fecal examinations at 8 to 10 weeks postinfection (PI) revealed 169 mice to be infected. More than half of them died within 30 weeks PI and 70 mice that survived to the 50th week PI were sacrificed. At autopsy, we could find no schistosome eggs in the liver or intestinal wall of 9 mice, and they were excluded. Out of 61 mice which showed S. japonicum eggs in their livers, 48 had single or multiple hepatoma, while no tumor was observed in the livers of the 60 control mice. The tumors were yellowish‐white in color with distinct boundaries and the centers of the tumors were depressed in some cases. The size of the tumors varied from 1 to 20 mm in diameter. Most of the tumors retained the normal trabecular pattern, but in some cases the trabeculae were thickened, having wide vascular spaces. The tumor cells were PAS‐negative and showed varieties of pleomorphism. The sizes of cells and nuclei varied greatly. These findings suggested some causal relationship between S. japonicum infection and the hepatoma formation in the host's liver. In the chronic course of Schistosomiasis japonica in the endemic areas, S. japonicum infection probably plays a role in hepatoma formation of patients.
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spelling pubmed-59174622018-05-11 Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica Amano, Teruaki Oshima, Tomoo Jpn J Cancer Res Article Three hundred and ninety‐five four‐week‐old SPF female ddY mice were each exposed to 5 or 6 cercariae of Schistosoma japonicum (Japanese strain) on their shaved abdomens and were maintained in a conditioned clean environment and fed on sterilized food and water. Fecal examinations at 8 to 10 weeks postinfection (PI) revealed 169 mice to be infected. More than half of them died within 30 weeks PI and 70 mice that survived to the 50th week PI were sacrificed. At autopsy, we could find no schistosome eggs in the liver or intestinal wall of 9 mice, and they were excluded. Out of 61 mice which showed S. japonicum eggs in their livers, 48 had single or multiple hepatoma, while no tumor was observed in the livers of the 60 control mice. The tumors were yellowish‐white in color with distinct boundaries and the centers of the tumors were depressed in some cases. The size of the tumors varied from 1 to 20 mm in diameter. Most of the tumors retained the normal trabecular pattern, but in some cases the trabeculae were thickened, having wide vascular spaces. The tumor cells were PAS‐negative and showed varieties of pleomorphism. The sizes of cells and nuclei varied greatly. These findings suggested some causal relationship between S. japonicum infection and the hepatoma formation in the host's liver. In the chronic course of Schistosomiasis japonica in the endemic areas, S. japonicum infection probably plays a role in hepatoma formation of patients. Blackwell Publishing Ltd 1988-02 /pmc/articles/PMC5917462/ /pubmed/3130351 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01574.x Text en
spellingShingle Article
Amano, Teruaki
Oshima, Tomoo
Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title_full Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title_fullStr Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title_full_unstemmed Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title_short Hepatoma Formation in ddY Mice with Chronic Schistosomiasis japonica
title_sort hepatoma formation in ddy mice with chronic schistosomiasis japonica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917462/
https://www.ncbi.nlm.nih.gov/pubmed/3130351
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01574.x
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