NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A

A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c‐myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the...

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Detalles Bibliográficos
Autores principales: Ochi, Hisako, Watanabe, Shaw, Yamamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917470/
https://www.ncbi.nlm.nih.gov/pubmed/3130346
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01568.x
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author Ochi, Hisako
Watanabe, Shaw
Yamamoto, Hiroshi
author_facet Ochi, Hisako
Watanabe, Shaw
Yamamoto, Hiroshi
author_sort Ochi, Hisako
collection PubMed
description A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c‐myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A.
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spelling pubmed-59174702018-05-11 NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A Ochi, Hisako Watanabe, Shaw Yamamoto, Hiroshi Jpn J Cancer Res Rapid Communication A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c‐myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A. Blackwell Publishing Ltd 1988-02 /pmc/articles/PMC5917470/ /pubmed/3130346 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01568.x Text en
spellingShingle Rapid Communication
Ochi, Hisako
Watanabe, Shaw
Yamamoto, Hiroshi
NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title_full NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title_fullStr NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title_full_unstemmed NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title_short NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
title_sort new heritable fragile site on chromosome 8 induced by distamycin a
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917470/
https://www.ncbi.nlm.nih.gov/pubmed/3130346
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01568.x
work_keys_str_mv AT ochihisako newheritablefragilesiteonchromosome8inducedbydistamycina
AT watanabeshaw newheritablefragilesiteonchromosome8inducedbydistamycina
AT yamamotohiroshi newheritablefragilesiteonchromosome8inducedbydistamycina

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