LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN

The amounts of mRNA for glutathione S transferase π (GST π) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakagawa, Kazuhiko, Yokota, Jun, Wada, Makio, Sasaki, Yasutsuna, Fujiwara, Yasuhiro, Sakai, Masaharu, Muramatsu, Masami, Terasaki, Takeo, Tsunokawa, Youko, Terada, Masaaki, Saijo, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917487/
https://www.ncbi.nlm.nih.gov/pubmed/2836347
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01590.x
_version_ 1783317221118836736
author Nakagawa, Kazuhiko
Yokota, Jun
Wada, Makio
Sasaki, Yasutsuna
Fujiwara, Yasuhiro
Sakai, Masaharu
Muramatsu, Masami
Terasaki, Takeo
Tsunokawa, Youko
Terada, Masaaki
Saijo, Nagahiro
author_facet Nakagawa, Kazuhiko
Yokota, Jun
Wada, Makio
Sasaki, Yasutsuna
Fujiwara, Yasuhiro
Sakai, Masaharu
Muramatsu, Masami
Terasaki, Takeo
Tsunokawa, Youko
Terada, Masaaki
Saijo, Nagahiro
author_sort Nakagawa, Kazuhiko
collection PubMed
description The amounts of mRNA for glutathione S transferase π (GST π) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell lines. These results indicate that low levels of GST π mRNA expression in SCLC cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, and further suggest that GST π may play an important role in intracellular inactivation of these drugs.
format Online
Article
Text
id pubmed-5917487
institution National Center for Biotechnology Information
language English
publishDate 1988
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59174872018-05-11 LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN Nakagawa, Kazuhiko Yokota, Jun Wada, Makio Sasaki, Yasutsuna Fujiwara, Yasuhiro Sakai, Masaharu Muramatsu, Masami Terasaki, Takeo Tsunokawa, Youko Terada, Masaaki Saijo, Nagahiro Jpn J Cancer Res Rapid Communication The amounts of mRNA for glutathione S transferase π (GST π) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell lines. These results indicate that low levels of GST π mRNA expression in SCLC cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, and further suggest that GST π may play an important role in intracellular inactivation of these drugs. Blackwell Publishing Ltd 1988-03 /pmc/articles/PMC5917487/ /pubmed/2836347 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01590.x Text en
spellingShingle Rapid Communication
Nakagawa, Kazuhiko
Yokota, Jun
Wada, Makio
Sasaki, Yasutsuna
Fujiwara, Yasuhiro
Sakai, Masaharu
Muramatsu, Masami
Terasaki, Takeo
Tsunokawa, Youko
Terada, Masaaki
Saijo, Nagahiro
LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title_full LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title_fullStr LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title_full_unstemmed LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title_short LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
title_sort levels of glutathiones transferase π mrna in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917487/
https://www.ncbi.nlm.nih.gov/pubmed/2836347
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01590.x
work_keys_str_mv AT nakagawakazuhiko levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT yokotajun levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT wadamakio levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT sasakiyasutsuna levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT fujiwarayasuhiro levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT sakaimasaharu levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT muramatsumasami levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT terasakitakeo levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT tsunokawayouko levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT teradamasaaki levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin
AT saijonagahiro levelsofglutathionestransferasepmrnainhumanlungcancercelllinescorrelatewiththeresistancetocisplatinandcarboplatin

Ejemplares similares