Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine

Studies were made on potential modifying effects of phenobarbital (PB) and carbazole on tumor development induced by N‐bis(2‐hydroxypropyl)nitrosamine (DHPN), a wide‐spectrum carcinogen in rats. Effects on the lung, thyroid, kidney, bladder and liver were investigated. Male F344 rats were given 0.2%...

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Detalles Bibliográficos
Autores principales: Shirai, Tomoyuki, Masuda, Atsuko, Imaida, Katsumi, Ogiso, Tadashi, Ito, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917507/
https://www.ncbi.nlm.nih.gov/pubmed/3133336
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01614.x
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author Shirai, Tomoyuki
Masuda, Atsuko
Imaida, Katsumi
Ogiso, Tadashi
Ito, Nobuyuki
author_facet Shirai, Tomoyuki
Masuda, Atsuko
Imaida, Katsumi
Ogiso, Tadashi
Ito, Nobuyuki
author_sort Shirai, Tomoyuki
collection PubMed
description Studies were made on potential modifying effects of phenobarbital (PB) and carbazole on tumor development induced by N‐bis(2‐hydroxypropyl)nitrosamine (DHPN), a wide‐spectrum carcinogen in rats. Effects on the lung, thyroid, kidney, bladder and liver were investigated. Male F344 rats were given 0.2% DHPN in their drinking water for 1 week and then 0.05% PB or 0.6% carbazole in their diet for 50 weeks. Control animals were treated with either DHPN or PB or carbazole only. Neither PB nor carbazole affected the incidence or histology of lung tumors. However, PB promoted the development of thyroid tumors and preneoplastic lesions of the liver, while carbazole promoted the induction of renal pelvic tumors.
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spelling pubmed-59175072018-05-11 Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine Shirai, Tomoyuki Masuda, Atsuko Imaida, Katsumi Ogiso, Tadashi Ito, Nobuyuki Jpn J Cancer Res Article Studies were made on potential modifying effects of phenobarbital (PB) and carbazole on tumor development induced by N‐bis(2‐hydroxypropyl)nitrosamine (DHPN), a wide‐spectrum carcinogen in rats. Effects on the lung, thyroid, kidney, bladder and liver were investigated. Male F344 rats were given 0.2% DHPN in their drinking water for 1 week and then 0.05% PB or 0.6% carbazole in their diet for 50 weeks. Control animals were treated with either DHPN or PB or carbazole only. Neither PB nor carbazole affected the incidence or histology of lung tumors. However, PB promoted the development of thyroid tumors and preneoplastic lesions of the liver, while carbazole promoted the induction of renal pelvic tumors. Blackwell Publishing Ltd 1988-04 /pmc/articles/PMC5917507/ /pubmed/3133336 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01614.x Text en
spellingShingle Article
Shirai, Tomoyuki
Masuda, Atsuko
Imaida, Katsumi
Ogiso, Tadashi
Ito, Nobuyuki
Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title_full Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title_fullStr Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title_full_unstemmed Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title_short Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
title_sort effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with n‐bis(2‐hydroxypropyl)nitrosamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917507/
https://www.ncbi.nlm.nih.gov/pubmed/3133336
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01614.x
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