Cargando…
A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS
Leukemic cells from four out of eight patients with adult T‐cell leukemia (ATL) were successfully grown by cocultivation with HSC‐I cells, a human skin cancer cell line, in the presence of interleukin‐2. Three of these four cultures of growing cells showed rearrangement of the T‐cell receptor β‐chai...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1988
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917511/ https://www.ncbi.nlm.nih.gov/pubmed/2898464 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01608.x |
_version_ | 1783317226746544128 |
---|---|
author | Kagami, Yoshitoyo Kinoshita, Tomohiro Shimoyama, Masanori Miwa, Masanao |
author_facet | Kagami, Yoshitoyo Kinoshita, Tomohiro Shimoyama, Masanori Miwa, Masanao |
author_sort | Kagami, Yoshitoyo |
collection | PubMed |
description | Leukemic cells from four out of eight patients with adult T‐cell leukemia (ATL) were successfully grown by cocultivation with HSC‐I cells, a human skin cancer cell line, in the presence of interleukin‐2. Three of these four cultures of growing cells showed rearrangement of the T‐cell receptor β‐chain gene like the original leukemic cells in vivo, and also showed conservation of the patterns of HTLV‐I integration of the original leukemic cells in vivo. Cell‐to‐cell contact between HSC‐I cells and leukemic cells was not necessary for growth of the leukemic cells. The results indicate that some soluble growth factor secreted by HSC‐I cells and interleukin‐2 are required for the in vitro growth of leukemic cells from some patients with adult T‐cell leukemia. |
format | Online Article Text |
id | pubmed-5917511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59175112018-05-11 A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS Kagami, Yoshitoyo Kinoshita, Tomohiro Shimoyama, Masanori Miwa, Masanao Jpn J Cancer Res Rapid Communication Leukemic cells from four out of eight patients with adult T‐cell leukemia (ATL) were successfully grown by cocultivation with HSC‐I cells, a human skin cancer cell line, in the presence of interleukin‐2. Three of these four cultures of growing cells showed rearrangement of the T‐cell receptor β‐chain gene like the original leukemic cells in vivo, and also showed conservation of the patterns of HTLV‐I integration of the original leukemic cells in vivo. Cell‐to‐cell contact between HSC‐I cells and leukemic cells was not necessary for growth of the leukemic cells. The results indicate that some soluble growth factor secreted by HSC‐I cells and interleukin‐2 are required for the in vitro growth of leukemic cells from some patients with adult T‐cell leukemia. Blackwell Publishing Ltd 1988-04 /pmc/articles/PMC5917511/ /pubmed/2898464 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01608.x Text en |
spellingShingle | Rapid Communication Kagami, Yoshitoyo Kinoshita, Tomohiro Shimoyama, Masanori Miwa, Masanao A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title | A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title_full | A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title_fullStr | A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title_full_unstemmed | A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title_short | A SOLUBLE‐FACTOR(S) SECRETED BY A HUMAN SKIN CANCER CELL LINE SUPPORTS CLONAL GROWTH OF ADULT T‐CELL LEUKEMIA CELLS |
title_sort | soluble‐factor(s) secreted by a human skin cancer cell line supports clonal growth of adult t‐cell leukemia cells |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917511/ https://www.ncbi.nlm.nih.gov/pubmed/2898464 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01608.x |
work_keys_str_mv | AT kagamiyoshitoyo asolublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT kinoshitatomohiro asolublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT shimoyamamasanori asolublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT miwamasanao asolublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT kagamiyoshitoyo solublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT kinoshitatomohiro solublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT shimoyamamasanori solublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells AT miwamasanao solublefactorssecretedbyahumanskincancercelllinesupportsclonalgrowthofadulttcellleukemiacells |