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Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors

CONTEXT: Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). It is the sixth leading cancer worldwide, with approximately 600,000 cases reported annually. It is one of the most common can...

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Autores principales: Verma, Jyoti, Dhingra, Vishal, Srivastava, Sapan, Misra, Vatsala, Varma, Kachnar, Singh, Shilpy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917517/
https://www.ncbi.nlm.nih.gov/pubmed/29731551
http://dx.doi.org/10.4103/jomfp.JOMFP_137_16
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author Verma, Jyoti
Dhingra, Vishal
Srivastava, Sapan
Misra, Vatsala
Varma, Kachnar
Singh, Shilpy
author_facet Verma, Jyoti
Dhingra, Vishal
Srivastava, Sapan
Misra, Vatsala
Varma, Kachnar
Singh, Shilpy
author_sort Verma, Jyoti
collection PubMed
description CONTEXT: Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). It is the sixth leading cancer worldwide, with approximately 600,000 cases reported annually. It is one of the most common cancers in India. AIMS AND OBJECTIVE: Epidermal growth factor receptor (EGFR) being the most promising marker has potentially offered new methods to prognosticate and plays an essential role in early diagnosis and treatment apart from tumor, node and metastasis staging which has been used till now. Therefore, this study has been undertaken to evaluate the expression of EGFR in HNSCC cases, according to the new scoring system and find its association with various pathological prognostic factors. MATERIALS AND METHODS: Forty-eight resected specimens of oral squamous cell carcinoma were received. Cases were appropriately staged, and paraffin-embedded tumor sections, stained with hematoxylin and eosin, were graded. EGFR expression was evaluated as extent score, intensity score and total score (TS). STATISTICAL ANALYSIS: Data obtained were transferred on to an excel sheet. Chi-square test with and without Yate's correction was employed to compare various parameters. P ≤ 0.05 was taken as critical level of significance. RESULTS: A significant association was observed between TS of EGFR expression and tumor grade but not with tumor stage or lymph node metastasis. CONCLUSION: A significant association of EGFR expression exists with tumor grade as per the new scoring system adopted. High EGFR expression suggests uncontrolled growth which depicts that EGFR upregulation may be an early event during HNSCC carcinogenesis.
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spelling pubmed-59175172018-05-04 Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors Verma, Jyoti Dhingra, Vishal Srivastava, Sapan Misra, Vatsala Varma, Kachnar Singh, Shilpy J Oral Maxillofac Pathol Original Article CONTEXT: Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). It is the sixth leading cancer worldwide, with approximately 600,000 cases reported annually. It is one of the most common cancers in India. AIMS AND OBJECTIVE: Epidermal growth factor receptor (EGFR) being the most promising marker has potentially offered new methods to prognosticate and plays an essential role in early diagnosis and treatment apart from tumor, node and metastasis staging which has been used till now. Therefore, this study has been undertaken to evaluate the expression of EGFR in HNSCC cases, according to the new scoring system and find its association with various pathological prognostic factors. MATERIALS AND METHODS: Forty-eight resected specimens of oral squamous cell carcinoma were received. Cases were appropriately staged, and paraffin-embedded tumor sections, stained with hematoxylin and eosin, were graded. EGFR expression was evaluated as extent score, intensity score and total score (TS). STATISTICAL ANALYSIS: Data obtained were transferred on to an excel sheet. Chi-square test with and without Yate's correction was employed to compare various parameters. P ≤ 0.05 was taken as critical level of significance. RESULTS: A significant association was observed between TS of EGFR expression and tumor grade but not with tumor stage or lymph node metastasis. CONCLUSION: A significant association of EGFR expression exists with tumor grade as per the new scoring system adopted. High EGFR expression suggests uncontrolled growth which depicts that EGFR upregulation may be an early event during HNSCC carcinogenesis. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5917517/ /pubmed/29731551 http://dx.doi.org/10.4103/jomfp.JOMFP_137_16 Text en Copyright: © 2018 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Verma, Jyoti
Dhingra, Vishal
Srivastava, Sapan
Misra, Vatsala
Varma, Kachnar
Singh, Shilpy
Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title_full Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title_fullStr Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title_full_unstemmed Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title_short Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
title_sort evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917517/
https://www.ncbi.nlm.nih.gov/pubmed/29731551
http://dx.doi.org/10.4103/jomfp.JOMFP_137_16
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