DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS

The DNA content of 1,2‐dimethylhydrazine (DMH)‐induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S‐phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma...

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Detalles Bibliográficos
Autores principales: Sano, Takeshi, Remvikos, Yorghos, Vielh, Philippe, Buisson, Jean Pierre, Manceau, Rogée, Salmon, Rémy Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917553/
https://www.ncbi.nlm.nih.gov/pubmed/3136109
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00025.x
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author Sano, Takeshi
Remvikos, Yorghos
Vielh, Philippe
Buisson, Jean Pierre
Manceau, Rogée
Salmon, Rémy Jacques
author_facet Sano, Takeshi
Remvikos, Yorghos
Vielh, Philippe
Buisson, Jean Pierre
Manceau, Rogée
Salmon, Rémy Jacques
author_sort Sano, Takeshi
collection PubMed
description The DNA content of 1,2‐dimethylhydrazine (DMH)‐induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S‐phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma‐carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers.
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spelling pubmed-59175532018-05-11 DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS Sano, Takeshi Remvikos, Yorghos Vielh, Philippe Buisson, Jean Pierre Manceau, Rogée Salmon, Rémy Jacques Jpn J Cancer Res Rapid Communication The DNA content of 1,2‐dimethylhydrazine (DMH)‐induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S‐phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma‐carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers. Blackwell Publishing Ltd 1988-05 /pmc/articles/PMC5917553/ /pubmed/3136109 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00025.x Text en
spellingShingle Rapid Communication
Sano, Takeshi
Remvikos, Yorghos
Vielh, Philippe
Buisson, Jean Pierre
Manceau, Rogée
Salmon, Rémy Jacques
DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title_full DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title_fullStr DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title_full_unstemmed DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title_short DNA PLOIDY IN 1,2‐DIMETHYL‐HYDRAZINE‐INDUCED RAT TUMORS
title_sort dna ploidy in 1,2‐dimethyl‐hydrazine‐induced rat tumors
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917553/
https://www.ncbi.nlm.nih.gov/pubmed/3136109
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00025.x
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