TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS

Both spontaneous (SOS) and 4‐hydroxyaminoquinoline 1‐oxide (4‐HAQO)‐induced osteosarcomas (COS) could be serially transplanted in the subcutaneous back space of syngeneic F344 rats, the success rate becoming 100% within 5 passage generations. Transplanted tumors demonstrated rapid growth and display...

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Autores principales: Mii, Yoshio, Tsursumi, Masahiro, Shiraiwa, Kazumi, Miyauchi, Yoshizumi, Hohnoki, Kanya, Maruyama, Hiroshi, Ogushi, Hajime, Masuhara, Kenji, Konishi, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917555/
https://www.ncbi.nlm.nih.gov/pubmed/3136111
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00027.x
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author Mii, Yoshio
Tsursumi, Masahiro
Shiraiwa, Kazumi
Miyauchi, Yoshizumi
Hohnoki, Kanya
Maruyama, Hiroshi
Ogushi, Hajime
Masuhara, Kenji
Konishi, Yoichi
author_facet Mii, Yoshio
Tsursumi, Masahiro
Shiraiwa, Kazumi
Miyauchi, Yoshizumi
Hohnoki, Kanya
Maruyama, Hiroshi
Ogushi, Hajime
Masuhara, Kenji
Konishi, Yoichi
author_sort Mii, Yoshio
collection PubMed
description Both spontaneous (SOS) and 4‐hydroxyaminoquinoline 1‐oxide (4‐HAQO)‐induced osteosarcomas (COS) could be serially transplanted in the subcutaneous back space of syngeneic F344 rats, the success rate becoming 100% within 5 passage generations. Transplanted tumors demonstrated rapid growth and displayed high potential for metastasis to the lung in later generations. Tbus, a 100% lung metastasis rate was observed for SOS after the 20th and for COS after the 14th generation. The histological features of the primary SOS and COS were retained during serial transfer. These model systems should be useful for investigation of the biology of this very important tumor type.
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spelling pubmed-59175552018-05-11 TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS Mii, Yoshio Tsursumi, Masahiro Shiraiwa, Kazumi Miyauchi, Yoshizumi Hohnoki, Kanya Maruyama, Hiroshi Ogushi, Hajime Masuhara, Kenji Konishi, Yoichi Jpn J Cancer Res Rapid Communication Both spontaneous (SOS) and 4‐hydroxyaminoquinoline 1‐oxide (4‐HAQO)‐induced osteosarcomas (COS) could be serially transplanted in the subcutaneous back space of syngeneic F344 rats, the success rate becoming 100% within 5 passage generations. Transplanted tumors demonstrated rapid growth and displayed high potential for metastasis to the lung in later generations. Tbus, a 100% lung metastasis rate was observed for SOS after the 20th and for COS after the 14th generation. The histological features of the primary SOS and COS were retained during serial transfer. These model systems should be useful for investigation of the biology of this very important tumor type. Blackwell Publishing Ltd 1988-05 /pmc/articles/PMC5917555/ /pubmed/3136111 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00027.x Text en
spellingShingle Rapid Communication
Mii, Yoshio
Tsursumi, Masahiro
Shiraiwa, Kazumi
Miyauchi, Yoshizumi
Hohnoki, Kanya
Maruyama, Hiroshi
Ogushi, Hajime
Masuhara, Kenji
Konishi, Yoichi
TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title_full TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title_fullStr TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title_full_unstemmed TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title_short TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
title_sort transplantable osteosarcomas with high lung metastatic potential in fischer 344 rats
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917555/
https://www.ncbi.nlm.nih.gov/pubmed/3136111
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00027.x
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