AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS

The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carci...

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Detalles Bibliográficos
Autores principales: Tsuda, Toshitaka, Nakatani, Hiroshi, Matsumura, Takashi, Yoshida, Kazuhiro, Tahara, Eiichi, Nishihira, Tetsuro, Sakamoto, Hiromi, Yoshida, Teruhiko, Terada, Masaaki, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917559/
https://www.ncbi.nlm.nih.gov/pubmed/3136110
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00026.x
Descripción
Sumario:The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst‐1 and c‐erbB‐1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst‐1 gene was detected in gastric and colorectal carcinomas.

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