AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS

The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carci...

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Autores principales: Tsuda, Toshitaka, Nakatani, Hiroshi, Matsumura, Takashi, Yoshida, Kazuhiro, Tahara, Eiichi, Nishihira, Tetsuro, Sakamoto, Hiromi, Yoshida, Teruhiko, Terada, Masaaki, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917559/
https://www.ncbi.nlm.nih.gov/pubmed/3136110
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00026.x
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author Tsuda, Toshitaka
Nakatani, Hiroshi
Matsumura, Takashi
Yoshida, Kazuhiro
Tahara, Eiichi
Nishihira, Tetsuro
Sakamoto, Hiromi
Yoshida, Teruhiko
Terada, Masaaki
Sugimura, Takashi
author_facet Tsuda, Toshitaka
Nakatani, Hiroshi
Matsumura, Takashi
Yoshida, Kazuhiro
Tahara, Eiichi
Nishihira, Tetsuro
Sakamoto, Hiromi
Yoshida, Teruhiko
Terada, Masaaki
Sugimura, Takashi
author_sort Tsuda, Toshitaka
collection PubMed
description The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst‐1 and c‐erbB‐1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst‐1 gene was detected in gastric and colorectal carcinomas.
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spelling pubmed-59175592018-05-11 AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS Tsuda, Toshitaka Nakatani, Hiroshi Matsumura, Takashi Yoshida, Kazuhiro Tahara, Eiichi Nishihira, Tetsuro Sakamoto, Hiromi Yoshida, Teruhiko Terada, Masaaki Sugimura, Takashi Jpn J Cancer Res Rapid Communication The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst‐1 and c‐erbB‐1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst‐1 gene was detected in gastric and colorectal carcinomas. Blackwell Publishing Ltd 1988-05 /pmc/articles/PMC5917559/ /pubmed/3136110 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00026.x Text en
spellingShingle Rapid Communication
Tsuda, Toshitaka
Nakatani, Hiroshi
Matsumura, Takashi
Yoshida, Kazuhiro
Tahara, Eiichi
Nishihira, Tetsuro
Sakamoto, Hiromi
Yoshida, Teruhiko
Terada, Masaaki
Sugimura, Takashi
AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title_full AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title_fullStr AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title_full_unstemmed AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title_short AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS
title_sort amplification of the hst‐1 gene in human esophageal carcinomas
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917559/
https://www.ncbi.nlm.nih.gov/pubmed/3136110
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00026.x
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