AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS

The N‐myc amplification unit was investigated using two restriction fragment length polymorphisms for SphI and PvuII which we previously found to occur in the 2nd intron and in the 3’region of the human N‐myc oncogene, respectively. All the three haplotypes which are dominant in the Japanese populat...

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Detalles Bibliográficos
Autores principales: Yamada, Masao, Kurosawa, Hidemitsu, Nakagawa, Yuichi, Nakagome, Yasuo, Tsuda, Tohru, Higashi, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917576/
https://www.ncbi.nlm.nih.gov/pubmed/2900826
http://dx.doi.org/10.1111/j.1349-7006.1988.tb02219.x
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author Yamada, Masao
Kurosawa, Hidemitsu
Nakagawa, Yuichi
Nakagome, Yasuo
Tsuda, Tohru
Higashi, Ken
author_facet Yamada, Masao
Kurosawa, Hidemitsu
Nakagawa, Yuichi
Nakagome, Yasuo
Tsuda, Tohru
Higashi, Ken
author_sort Yamada, Masao
collection PubMed
description The N‐myc amplification unit was investigated using two restriction fragment length polymorphisms for SphI and PvuII which we previously found to occur in the 2nd intron and in the 3’region of the human N‐myc oncogene, respectively. All the three haplotypes which are dominant in the Japanese population were observed in the amplified DNA after analyses of a total of 22 DNA samples of fresh neuroblastomas with N‐myc amplification. We conclude that only one of the alleles was amplified and that either allele could be amplified with respect to both the SphI and PvuII polymorphisms.
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spelling pubmed-59175762018-05-11 AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS Yamada, Masao Kurosawa, Hidemitsu Nakagawa, Yuichi Nakagome, Yasuo Tsuda, Tohru Higashi, Ken Jpn J Cancer Res Rapid Communication The N‐myc amplification unit was investigated using two restriction fragment length polymorphisms for SphI and PvuII which we previously found to occur in the 2nd intron and in the 3’region of the human N‐myc oncogene, respectively. All the three haplotypes which are dominant in the Japanese population were observed in the amplified DNA after analyses of a total of 22 DNA samples of fresh neuroblastomas with N‐myc amplification. We conclude that only one of the alleles was amplified and that either allele could be amplified with respect to both the SphI and PvuII polymorphisms. Blackwell Publishing Ltd 1988-06 /pmc/articles/PMC5917576/ /pubmed/2900826 http://dx.doi.org/10.1111/j.1349-7006.1988.tb02219.x Text en
spellingShingle Rapid Communication
Yamada, Masao
Kurosawa, Hidemitsu
Nakagawa, Yuichi
Nakagome, Yasuo
Tsuda, Tohru
Higashi, Ken
AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title_full AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title_fullStr AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title_full_unstemmed AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title_short AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
title_sort amplified allele of the human n‐myc oncogene in neuroblastomas
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917576/
https://www.ncbi.nlm.nih.gov/pubmed/2900826
http://dx.doi.org/10.1111/j.1349-7006.1988.tb02219.x
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