MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES

Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml w...

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Detalles Bibliográficos
Autor principal: Aoki, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917583/
https://www.ncbi.nlm.nih.gov/pubmed/3137194
http://dx.doi.org/10.1111/j.1349-7006.1988.tb02223.x
Descripción
Sumario:Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml when lymphocytes were treated with the protease at 37° for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.

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