MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES

Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml w...

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Detalles Bibliográficos
Autor principal: Aoki, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917583/
https://www.ncbi.nlm.nih.gov/pubmed/3137194
http://dx.doi.org/10.1111/j.1349-7006.1988.tb02223.x
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author Aoki, Yosuke
author_facet Aoki, Yosuke
author_sort Aoki, Yosuke
collection PubMed
description Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml when lymphocytes were treated with the protease at 37° for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.
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spelling pubmed-59175832018-05-11 MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES Aoki, Yosuke Jpn J Cancer Res Rapid Communication Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml when lymphocytes were treated with the protease at 37° for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment. Blackwell Publishing Ltd 1988-06 /pmc/articles/PMC5917583/ /pubmed/3137194 http://dx.doi.org/10.1111/j.1349-7006.1988.tb02223.x Text en
spellingShingle Rapid Communication
Aoki, Yosuke
MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title_full MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title_fullStr MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title_full_unstemmed MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title_short MEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
title_sort medullasin induces activated killer cells from human lymphocytes
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917583/
https://www.ncbi.nlm.nih.gov/pubmed/3137194
http://dx.doi.org/10.1111/j.1349-7006.1988.tb02223.x
work_keys_str_mv AT aokiyosuke medullasininducesactivatedkillercellsfromhumanlymphocytes

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