IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS

Fifty million lymphokine‐activated killer (LAK) cells were infused into rat T9 gliosarcoma tumors for 1 hr at an infusion rate of 0.1 ml/hr. Cultured normal spleen cells were infused into similar tumors as a control. The LAK cell‐treated tumors began to regress at approximately 3 weeks after infusio...

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Detalles Bibliográficos
Autores principales: Yamaki, Toshiaki, Ibayashi, Yukihiro, Nakamura, Toru, Shubo, Noriharu, Daibo, Masahiko, Kawahara, Takahisa, Hashi, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917609/
https://www.ncbi.nlm.nih.gov/pubmed/3141326
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00053.x
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author Yamaki, Toshiaki
Ibayashi, Yukihiro
Nakamura, Toru
Shubo, Noriharu
Daibo, Masahiko
Kawahara, Takahisa
Hashi, Kazuo
author_facet Yamaki, Toshiaki
Ibayashi, Yukihiro
Nakamura, Toru
Shubo, Noriharu
Daibo, Masahiko
Kawahara, Takahisa
Hashi, Kazuo
author_sort Yamaki, Toshiaki
collection PubMed
description Fifty million lymphokine‐activated killer (LAK) cells were infused into rat T9 gliosarcoma tumors for 1 hr at an infusion rate of 0.1 ml/hr. Cultured normal spleen cells were infused into similar tumors as a control. The LAK cell‐treated tumors began to regress at approximately 3 weeks after infusion and disappeared by 6 weeks, while the cultured normal spleen cell‐treated tumors grew progressively. Immunohistochemical analysis demonstrated prominent infiltration of cytotoxic/suppressor T cells in the LAK cell‐treated tumors, while few lymphocytes were recognized in the control tumors. These data suggested that LAK cells infused intratumorally might be capable of mediating tumor regression by inducing host immunity against the tumor.
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spelling pubmed-59176092018-05-11 IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS Yamaki, Toshiaki Ibayashi, Yukihiro Nakamura, Toru Shubo, Noriharu Daibo, Masahiko Kawahara, Takahisa Hashi, Kazuo Jpn J Cancer Res Rapid Communication Fifty million lymphokine‐activated killer (LAK) cells were infused into rat T9 gliosarcoma tumors for 1 hr at an infusion rate of 0.1 ml/hr. Cultured normal spleen cells were infused into similar tumors as a control. The LAK cell‐treated tumors began to regress at approximately 3 weeks after infusion and disappeared by 6 weeks, while the cultured normal spleen cell‐treated tumors grew progressively. Immunohistochemical analysis demonstrated prominent infiltration of cytotoxic/suppressor T cells in the LAK cell‐treated tumors, while few lymphocytes were recognized in the control tumors. These data suggested that LAK cells infused intratumorally might be capable of mediating tumor regression by inducing host immunity against the tumor. Blackwell Publishing Ltd 1988-08 /pmc/articles/PMC5917609/ /pubmed/3141326 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00053.x Text en
spellingShingle Rapid Communication
Yamaki, Toshiaki
Ibayashi, Yukihiro
Nakamura, Toru
Shubo, Noriharu
Daibo, Masahiko
Kawahara, Takahisa
Hashi, Kazuo
IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title_full IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title_fullStr IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title_full_unstemmed IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title_short IMMUNOTHERAPY OF SOLID TOMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE‐ACTIVATED KILLER CELLS
title_sort immunotherapy of solid tomor by intratumoral infusion of lymphokine‐activated killer cells
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917609/
https://www.ncbi.nlm.nih.gov/pubmed/3141326
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00053.x
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