Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde

Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa...

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Detalles Bibliográficos
Autores principales: Furihata, Chie, Yamakoshi, Akira, Matsushima, Taijiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917613/
https://www.ncbi.nlm.nih.gov/pubmed/3141327
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00055.x
Descripción
Sumario:Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor‐promoting activity in carcinogenesis in the glandular stomach.

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