Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde

Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa...

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Autores principales: Furihata, Chie, Yamakoshi, Akira, Matsushima, Taijiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917613/
https://www.ncbi.nlm.nih.gov/pubmed/3141327
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00055.x
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author Furihata, Chie
Yamakoshi, Akira
Matsushima, Taijiro
author_facet Furihata, Chie
Yamakoshi, Akira
Matsushima, Taijiro
author_sort Furihata, Chie
collection PubMed
description Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor‐promoting activity in carcinogenesis in the glandular stomach.
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spelling pubmed-59176132018-05-11 Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde Furihata, Chie Yamakoshi, Akira Matsushima, Taijiro Jpn J Cancer Res Article Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor‐promoting activity in carcinogenesis in the glandular stomach. Blackwell Publishing Ltd 1988-08 /pmc/articles/PMC5917613/ /pubmed/3141327 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00055.x Text en
spellingShingle Article
Furihata, Chie
Yamakoshi, Akira
Matsushima, Taijiro
Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title_full Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title_fullStr Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title_full_unstemmed Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title_short Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
title_sort inductions of ornithine decarboxylase and dna synthesis in rat stomach mucosa by formaldehyde
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917613/
https://www.ncbi.nlm.nih.gov/pubmed/3141327
http://dx.doi.org/10.1111/j.1349-7006.1988.tb00055.x
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