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DNA Alkylation by Nitrosobis‐(2‐oxopropyl) amine in Rats of Different Ages

We have examined the methylation of liver DNA (O(6)‐ and N(7)‐methylguanine) by nitrosobis‐(2‐oxopropyl)amine (BOP) in male and female rats at various ages, following treatment with 2.5 mg of BOP; this dose given twice weekly for 30 weeks induces tumors in all animals. Except in young rats there was...

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Detalles Bibliográficos
Autores principales:	Lhomas, Barbara J., Lijinsky, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1988
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917622/ https://www.ncbi.nlm.nih.gov/pubmed/3142834 http://dx.doi.org/10.1111/j.1349-7006.1988.tb00071.x

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