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Vincristine‐resistant Human Cancer KB Cell Line and Increased Expression of Multidrug‐resistance Gene

A multidrug‐resistant clone of human cancer KB cells was isolated by stepwise selection on exposure to increasing doses of vincristine. The final clone, VJ‐300, obtained after ethylmethane sulfonate mutagenesis showed 400‐fold higher resistance to vincristine than did KB cells. Cellular accumulation...

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Detalles Bibliográficos
Autores principales:	Kohno, Kimitoshi, Kikuchi, Junko, Sato, Shin‐ichi, Takano, Hiroshi, Saburi, Yoshio, Asoh, Kuni‐ichi, Kuwano, Michihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1988
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917651/ https://www.ncbi.nlm.nih.gov/pubmed/2906349 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01550.x

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