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Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice
All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X‐irradiation with 20–60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose‐dependent regression. Hyperthermia for 30 min at 43.0° alone had little effect. However...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1988
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917659/ https://www.ncbi.nlm.nih.gov/pubmed/3148607 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01567.x |
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author | Sato, Setsu Ootsuyama, Akira Tanooka, Hiroshi |
author_facet | Sato, Setsu Ootsuyama, Akira Tanooka, Hiroshi |
author_sort | Sato, Setsu |
collection | PubMed |
description | All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X‐irradiation with 20–60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose‐dependent regression. Hyperthermia for 30 min at 43.0° alone had little effect. However, in 2 of 16 mice, hyperthermia after irradiation at 60 Gy resulted in complete cure, i.e., survival of mice without recurrence for more than 120 days after treatment. These results indicate that the combined treatment of radiation and hyperthermia is necessary to obtain the cure of mouse autochthonous tumors. |
format | Online Article Text |
id | pubmed-5917659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59176592018-05-11 Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice Sato, Setsu Ootsuyama, Akira Tanooka, Hiroshi Jpn J Cancer Res Article All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X‐irradiation with 20–60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose‐dependent regression. Hyperthermia for 30 min at 43.0° alone had little effect. However, in 2 of 16 mice, hyperthermia after irradiation at 60 Gy resulted in complete cure, i.e., survival of mice without recurrence for more than 120 days after treatment. These results indicate that the combined treatment of radiation and hyperthermia is necessary to obtain the cure of mouse autochthonous tumors. Blackwell Publishing Ltd 1988-12 /pmc/articles/PMC5917659/ /pubmed/3148607 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01567.x Text en |
spellingShingle | Article Sato, Setsu Ootsuyama, Akira Tanooka, Hiroshi Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title | Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title_full | Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title_fullStr | Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title_full_unstemmed | Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title_short | Radiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice |
title_sort | radiation, hyperthermia, and their combination in treatment of chemically induced autochthonous tumors in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917659/ https://www.ncbi.nlm.nih.gov/pubmed/3148607 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01567.x |
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