HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE

Argyrophil small cell carcinoma of the uterine cervix (ASCC) containing human papillomavirus type 16 (HPV16) DNA has been successfully transplanted in nude mice for the first time, and we have designated the resultant cell line as YIK‐1. Histology of YIK‐1 was similar to that of the original tumor....

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Detalles Bibliográficos
Autores principales: Ichimura, Hiroshi, Yamasaki, Masato, Yamane, Tetsumi, Shimizu, Hiromu, Katsumoto, Tetsuo, Kurimura, Osamu, Kurimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917665/
https://www.ncbi.nlm.nih.gov/pubmed/2853149
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01552.x
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author Ichimura, Hiroshi
Yamasaki, Masato
Yamane, Tetsumi
Shimizu, Hiromu
Katsumoto, Tetsuo
Kurimura, Osamu
Kurimura, Takashi
author_facet Ichimura, Hiroshi
Yamasaki, Masato
Yamane, Tetsumi
Shimizu, Hiromu
Katsumoto, Tetsuo
Kurimura, Osamu
Kurimura, Takashi
author_sort Ichimura, Hiroshi
collection PubMed
description Argyrophil small cell carcinoma of the uterine cervix (ASCC) containing human papillomavirus type 16 (HPV16) DNA has been successfully transplanted in nude mice for the first time, and we have designated the resultant cell line as YIK‐1. Histology of YIK‐1 was similar to that of the original tumor. The original and YIK‐1 tumor cells contained argyrophil granules and neurosecretory granules in the cytoplasm, and were immunohistochemically stained positive for neuron‐specific enolase, serotonin and chromogranin. Both tumors contained HPV16 DNA in a multiple‐copy integrated form. Thus, YIK‐1 maintains the characteristics of the original ASCC, and may therefore be useful as an animal system for experimental studies of ASCC.
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spelling pubmed-59176652018-05-11 HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE Ichimura, Hiroshi Yamasaki, Masato Yamane, Tetsumi Shimizu, Hiromu Katsumoto, Tetsuo Kurimura, Osamu Kurimura, Takashi Jpn J Cancer Res Rapid Communication Argyrophil small cell carcinoma of the uterine cervix (ASCC) containing human papillomavirus type 16 (HPV16) DNA has been successfully transplanted in nude mice for the first time, and we have designated the resultant cell line as YIK‐1. Histology of YIK‐1 was similar to that of the original tumor. The original and YIK‐1 tumor cells contained argyrophil granules and neurosecretory granules in the cytoplasm, and were immunohistochemically stained positive for neuron‐specific enolase, serotonin and chromogranin. Both tumors contained HPV16 DNA in a multiple‐copy integrated form. Thus, YIK‐1 maintains the characteristics of the original ASCC, and may therefore be useful as an animal system for experimental studies of ASCC. Blackwell Publishing Ltd 1988-12 /pmc/articles/PMC5917665/ /pubmed/2853149 http://dx.doi.org/10.1111/j.1349-7006.1988.tb01552.x Text en
spellingShingle Rapid Communication
Ichimura, Hiroshi
Yamasaki, Masato
Yamane, Tetsumi
Shimizu, Hiromu
Katsumoto, Tetsuo
Kurimura, Osamu
Kurimura, Takashi
HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title_full HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title_fullStr HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title_full_unstemmed HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title_short HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
title_sort heterotransplantation of argyrophil small cell carcinoma of the uterine cervix integrating hpv16 dna into nude mice
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917665/
https://www.ncbi.nlm.nih.gov/pubmed/2853149
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01552.x
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