Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma

Fourteen human bone and soft part tumor tissues were screened by Southern blot hybridization using five oncogene probes (c‐myc, c‐K‐ras, c‐fos, c‐raf‐l, and N‐myc). Amplification of c‐myc was found in two osteosarcomas and one malignant fibrous histiocytoma. One of these osteosarcomas had amplified...

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Autores principales: Ikeda, Shogo, Sumii, Hiroshi, Akiyama, Kosuke, Watanabe, Sekiko, Ito, Shiro, Inoue, Hajime, Takechi, Hideo, Tanabe, Gozo, Oda, Takuzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917676/
https://www.ncbi.nlm.nih.gov/pubmed/2496060
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02236.x
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author Ikeda, Shogo
Sumii, Hiroshi
Akiyama, Kosuke
Watanabe, Sekiko
Ito, Shiro
Inoue, Hajime
Takechi, Hideo
Tanabe, Gozo
Oda, Takuzo
author_facet Ikeda, Shogo
Sumii, Hiroshi
Akiyama, Kosuke
Watanabe, Sekiko
Ito, Shiro
Inoue, Hajime
Takechi, Hideo
Tanabe, Gozo
Oda, Takuzo
author_sort Ikeda, Shogo
collection PubMed
description Fourteen human bone and soft part tumor tissues were screened by Southern blot hybridization using five oncogene probes (c‐myc, c‐K‐ras, c‐fos, c‐raf‐l, and N‐myc). Amplification of c‐myc was found in two osteosarcomas and one malignant fibrous histiocytoma. One of these osteosarcomas had amplified c‐raf‐1 gene. Rearrangement of the amplified gene was not observed. This is the first report of c‐raf‐1 amplification in human cancer tissues.
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spelling pubmed-59176762018-05-11 Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma Ikeda, Shogo Sumii, Hiroshi Akiyama, Kosuke Watanabe, Sekiko Ito, Shiro Inoue, Hajime Takechi, Hideo Tanabe, Gozo Oda, Takuzo Jpn J Cancer Res Article Fourteen human bone and soft part tumor tissues were screened by Southern blot hybridization using five oncogene probes (c‐myc, c‐K‐ras, c‐fos, c‐raf‐l, and N‐myc). Amplification of c‐myc was found in two osteosarcomas and one malignant fibrous histiocytoma. One of these osteosarcomas had amplified c‐raf‐1 gene. Rearrangement of the amplified gene was not observed. This is the first report of c‐raf‐1 amplification in human cancer tissues. Blackwell Publishing Ltd 1989-01 /pmc/articles/PMC5917676/ /pubmed/2496060 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02236.x Text en
spellingShingle Article
Ikeda, Shogo
Sumii, Hiroshi
Akiyama, Kosuke
Watanabe, Sekiko
Ito, Shiro
Inoue, Hajime
Takechi, Hideo
Tanabe, Gozo
Oda, Takuzo
Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title_full Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title_fullStr Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title_full_unstemmed Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title_short Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
title_sort amplification of both c‐myc and c‐raf‐1 oncogenes in a human osteosarcoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917676/
https://www.ncbi.nlm.nih.gov/pubmed/2496060
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02236.x
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