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Modification of Cellular Membrane Functions by Pendolmycin
Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1989
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917687/ https://www.ncbi.nlm.nih.gov/pubmed/2496055 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02238.x |
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author | Umezawa, Kazuo Imoto, Masaya Yamashita, Takashi Sawa, Tsutomu Takeuchi, Tomio |
author_facet | Umezawa, Kazuo Imoto, Masaya Yamashita, Takashi Sawa, Tsutomu Takeuchi, Tomio |
author_sort | Umezawa, Kazuo |
collection | PubMed |
description | Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them. |
format | Online Article Text |
id | pubmed-5917687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1989 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59176872018-05-11 Modification of Cellular Membrane Functions by Pendolmycin Umezawa, Kazuo Imoto, Masaya Yamashita, Takashi Sawa, Tsutomu Takeuchi, Tomio Jpn J Cancer Res Rapid Communication Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them. Blackwell Publishing Ltd 1989-01 /pmc/articles/PMC5917687/ /pubmed/2496055 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02238.x Text en |
spellingShingle | Rapid Communication Umezawa, Kazuo Imoto, Masaya Yamashita, Takashi Sawa, Tsutomu Takeuchi, Tomio Modification of Cellular Membrane Functions by Pendolmycin |
title | Modification of Cellular Membrane Functions by Pendolmycin |
title_full | Modification of Cellular Membrane Functions by Pendolmycin |
title_fullStr | Modification of Cellular Membrane Functions by Pendolmycin |
title_full_unstemmed | Modification of Cellular Membrane Functions by Pendolmycin |
title_short | Modification of Cellular Membrane Functions by Pendolmycin |
title_sort | modification of cellular membrane functions by pendolmycin |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917687/ https://www.ncbi.nlm.nih.gov/pubmed/2496055 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02238.x |
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