Mutations of N‐ras Oncogene in Myelodysplastic Syndromes and Lcukemias Detected by Polymerase Chain Reaction

By using polymerase chain reaction and differential hybridization, point mutations of N‐ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N‐ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation...

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Detalles Bibliográficos
Autores principales: Mano, Hiroyuki, Ishikawa, Fuyuki, Hirai, Hisamaru, Takaku, Fumimaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917694/
https://www.ncbi.nlm.nih.gov/pubmed/2498243
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02274.x
Descripción
Sumario:By using polymerase chain reaction and differential hybridization, point mutations of N‐ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N‐ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.

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