Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection

A 10‐year‐old boy with chronic active Epstein‐Barr virus (EBV) infection developed T‐cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3(±), CD4(±) and HLA‐DR(±). The genomic DNAs from these cells demonstrated two rearranged T‐c...

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Autores principales: Ishihara, Shigehiko, Tawa, Akio, Yumura‐Yagi, Keiko, Murata, Mitsunori, Hara, Jun‐ichi, Yabuuchi, Hyakuji, Hirai, Kanji, Kawa‐Ha, Keisei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917706/
https://www.ncbi.nlm.nih.gov/pubmed/2542204
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02273.x
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author Ishihara, Shigehiko
Tawa, Akio
Yumura‐Yagi, Keiko
Murata, Mitsunori
Hara, Jun‐ichi
Yabuuchi, Hyakuji
Hirai, Kanji
Kawa‐Ha, Keisei
author_facet Ishihara, Shigehiko
Tawa, Akio
Yumura‐Yagi, Keiko
Murata, Mitsunori
Hara, Jun‐ichi
Yabuuchi, Hyakuji
Hirai, Kanji
Kawa‐Ha, Keisei
author_sort Ishihara, Shigehiko
collection PubMed
description A 10‐year‐old boy with chronic active Epstein‐Barr virus (EBV) infection developed T‐cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3(±), CD4(±) and HLA‐DR(±). The genomic DNAs from these cells demonstrated two rearranged T‐cell receptor μ‐chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T‐cell lymphoproliferation.
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spelling pubmed-59177062018-05-11 Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection Ishihara, Shigehiko Tawa, Akio Yumura‐Yagi, Keiko Murata, Mitsunori Hara, Jun‐ichi Yabuuchi, Hyakuji Hirai, Kanji Kawa‐Ha, Keisei Jpn J Cancer Res Article A 10‐year‐old boy with chronic active Epstein‐Barr virus (EBV) infection developed T‐cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3(±), CD4(±) and HLA‐DR(±). The genomic DNAs from these cells demonstrated two rearranged T‐cell receptor μ‐chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T‐cell lymphoproliferation. Blackwell Publishing Ltd 1989-02 /pmc/articles/PMC5917706/ /pubmed/2542204 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02273.x Text en
spellingShingle Article
Ishihara, Shigehiko
Tawa, Akio
Yumura‐Yagi, Keiko
Murata, Mitsunori
Hara, Jun‐ichi
Yabuuchi, Hyakuji
Hirai, Kanji
Kawa‐Ha, Keisei
Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title_full Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title_fullStr Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title_full_unstemmed Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title_short Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
title_sort clonal t‐cell lymphoproliferation containing epstein‐barr (eb) virus dna in a patient with chronic active eb virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917706/
https://www.ncbi.nlm.nih.gov/pubmed/2542204
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02273.x
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