The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects

Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer‐free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal cont...

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Autores principales: Miki, Kazumasa, Ichinose, Masao, Kawamura, Norio, Matsushima, Masashi, Ahmad, Haron Bin, Kimura, Masayoshi, Sano, Junjiro, Tashiro, Takao, Kakei, Nobuyuki, Oka, Hiroshi, Furihata, Chie, Takahashi, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917707/
https://www.ncbi.nlm.nih.gov/pubmed/2498245
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02276.x
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author Miki, Kazumasa
Ichinose, Masao
Kawamura, Norio
Matsushima, Masashi
Ahmad, Haron Bin
Kimura, Masayoshi
Sano, Junjiro
Tashiro, Takao
Kakei, Nobuyuki
Oka, Hiroshi
Furihata, Chie
Takahashi, Kenji
author_facet Miki, Kazumasa
Ichinose, Masao
Kawamura, Norio
Matsushima, Masashi
Ahmad, Haron Bin
Kimura, Masayoshi
Sano, Junjiro
Tashiro, Takao
Kakei, Nobuyuki
Oka, Hiroshi
Furihata, Chie
Takahashi, Kenji
author_sort Miki, Kazumasa
collection PubMed
description Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer‐free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non‐invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer.
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spelling pubmed-59177072018-05-11 The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects Miki, Kazumasa Ichinose, Masao Kawamura, Norio Matsushima, Masashi Ahmad, Haron Bin Kimura, Masayoshi Sano, Junjiro Tashiro, Takao Kakei, Nobuyuki Oka, Hiroshi Furihata, Chie Takahashi, Kenji Jpn J Cancer Res Rapid Communication Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer‐free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non‐invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer. Blackwell Publishing Ltd 1989-02 /pmc/articles/PMC5917707/ /pubmed/2498245 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02276.x Text en
spellingShingle Rapid Communication
Miki, Kazumasa
Ichinose, Masao
Kawamura, Norio
Matsushima, Masashi
Ahmad, Haron Bin
Kimura, Masayoshi
Sano, Junjiro
Tashiro, Takao
Kakei, Nobuyuki
Oka, Hiroshi
Furihata, Chie
Takahashi, Kenji
The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title_full The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title_fullStr The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title_full_unstemmed The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title_short The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
title_sort significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in japanese subjects
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917707/
https://www.ncbi.nlm.nih.gov/pubmed/2498245
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02276.x
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