Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia

The age‐specific occurrence of adult T‐cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log‐linear in this model and the curves for...

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Autores principales: Okarmoto, Takashi, Ohno, Yuko, Tsugane, Shoichiro, Watanabe, Shaw, Shimoyama, Masanori, Tajima, Kazuo, Miwa, Masanao, Shimotohno, Kunitada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917708/
https://www.ncbi.nlm.nih.gov/pubmed/2498254
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02289.x
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author Okarmoto, Takashi
Ohno, Yuko
Tsugane, Shoichiro
Watanabe, Shaw
Shimoyama, Masanori
Tajima, Kazuo
Miwa, Masanao
Shimotohno, Kunitada
author_facet Okarmoto, Takashi
Ohno, Yuko
Tsugane, Shoichiro
Watanabe, Shaw
Shimoyama, Masanori
Tajima, Kazuo
Miwa, Masanao
Shimotohno, Kunitada
author_sort Okarmoto, Takashi
collection PubMed
description The age‐specific occurrence of adult T‐cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log‐linear in this model and the curves for males and females overlapped completely. The presence of age‐dependent accumulation of leukemogenic events within human T‐cell leukemia virus type 1‐immortalized T cells was suggested prior to the development of ATL, and the approximate number of independent leukemogenic events in ATL is estimated to be five. This stochastic analysis supported a multi‐step carcinogenesis as an appropriate model for ATL.
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spelling pubmed-59177082018-05-11 Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia Okarmoto, Takashi Ohno, Yuko Tsugane, Shoichiro Watanabe, Shaw Shimoyama, Masanori Tajima, Kazuo Miwa, Masanao Shimotohno, Kunitada Jpn J Cancer Res Rapid Communication The age‐specific occurrence of adult T‐cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log‐linear in this model and the curves for males and females overlapped completely. The presence of age‐dependent accumulation of leukemogenic events within human T‐cell leukemia virus type 1‐immortalized T cells was suggested prior to the development of ATL, and the approximate number of independent leukemogenic events in ATL is estimated to be five. This stochastic analysis supported a multi‐step carcinogenesis as an appropriate model for ATL. Blackwell Publishing Ltd 1989-03 /pmc/articles/PMC5917708/ /pubmed/2498254 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02289.x Text en
spellingShingle Rapid Communication
Okarmoto, Takashi
Ohno, Yuko
Tsugane, Shoichiro
Watanabe, Shaw
Shimoyama, Masanori
Tajima, Kazuo
Miwa, Masanao
Shimotohno, Kunitada
Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title_full Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title_fullStr Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title_full_unstemmed Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title_short Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
title_sort multi‐step carcinogenesis model for adult t‐cell leukemia
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917708/
https://www.ncbi.nlm.nih.gov/pubmed/2498254
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02289.x
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