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Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells
The effect of transforming growth factor‐β (TGF‐β) on induction of differentiation of mouse myeloid leukemia M1 cells was investigated. TGF‐β1 induced adherence of M1 cells to plastic dishes and inhibited their proliferation. However, it did not induce differentiation‐associated properties, such as...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1989
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917715/ https://www.ncbi.nlm.nih.gov/pubmed/2498257 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02297.x |
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author | Okabe‐Kado, Junko Honma, Yoshio Hayashi, Moriaki Hozumi, Motoo |
author_facet | Okabe‐Kado, Junko Honma, Yoshio Hayashi, Moriaki Hozumi, Motoo |
author_sort | Okabe‐Kado, Junko |
collection | PubMed |
description | The effect of transforming growth factor‐β (TGF‐β) on induction of differentiation of mouse myeloid leukemia M1 cells was investigated. TGF‐β1 induced adherence of M1 cells to plastic dishes and inhibited their proliferation. However, it did not induce differentiation‐associated properties, such as phagocytic activity, lysozyme activity or morphological maturation. TGF‐β1 also caused dosedependent inhibition of dexamethasone‐induced differentiation of M1 cells. The inhibitory activity of TGF‐β1 was 20 times that of TGF‐β2 on M1 cells. These results suggest that TGF‐β1 inhibits proliferation and dexamethasone‐induced differentiation of M1 cells by interacting with receptors that can distinguish between TGF‐β1 and TGF‐β2. TGF‐β1 had a much lower inhibitory effect on the growth of a variant M1 cell clone, which was resistant to differentiation inducers, and it did not induce adherence of the resistant M1 cells. |
format | Online Article Text |
id | pubmed-5917715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1989 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59177152018-05-11 Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells Okabe‐Kado, Junko Honma, Yoshio Hayashi, Moriaki Hozumi, Motoo Jpn J Cancer Res Article The effect of transforming growth factor‐β (TGF‐β) on induction of differentiation of mouse myeloid leukemia M1 cells was investigated. TGF‐β1 induced adherence of M1 cells to plastic dishes and inhibited their proliferation. However, it did not induce differentiation‐associated properties, such as phagocytic activity, lysozyme activity or morphological maturation. TGF‐β1 also caused dosedependent inhibition of dexamethasone‐induced differentiation of M1 cells. The inhibitory activity of TGF‐β1 was 20 times that of TGF‐β2 on M1 cells. These results suggest that TGF‐β1 inhibits proliferation and dexamethasone‐induced differentiation of M1 cells by interacting with receptors that can distinguish between TGF‐β1 and TGF‐β2. TGF‐β1 had a much lower inhibitory effect on the growth of a variant M1 cell clone, which was resistant to differentiation inducers, and it did not induce adherence of the resistant M1 cells. Blackwell Publishing Ltd 1989-03 /pmc/articles/PMC5917715/ /pubmed/2498257 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02297.x Text en |
spellingShingle | Article Okabe‐Kado, Junko Honma, Yoshio Hayashi, Moriaki Hozumi, Motoo Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title | Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title_full | Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title_fullStr | Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title_full_unstemmed | Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title_short | Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells |
title_sort | inhibitory action of transforming growth factor‐β on induction of differentiation of myeloid leukemia cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917715/ https://www.ncbi.nlm.nih.gov/pubmed/2498257 http://dx.doi.org/10.1111/j.1349-7006.1989.tb02297.x |
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