Cargando…

Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation

L‐Alanosine, an analog of L‐aspartie acid, was investigated as one of a series of chemical compounds that may have inhibitory effects on the repair of potentially lethal damage caused by radiation using an in vivo murine fibrosarcoma (Meth‐A tumor) in BALB/cBy male mice. The combined treatment of si...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Seong Su, Alfieri, Alan A., Kim, Sang Hie, Kim, Jae Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917789/
https://www.ncbi.nlm.nih.gov/pubmed/2503478
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01680.x
_version_ 1783317288442658816
author Hong, Seong Su
Alfieri, Alan A.
Kim, Sang Hie
Kim, Jae Ho
author_facet Hong, Seong Su
Alfieri, Alan A.
Kim, Sang Hie
Kim, Jae Ho
author_sort Hong, Seong Su
collection PubMed
description L‐Alanosine, an analog of L‐aspartie acid, was investigated as one of a series of chemical compounds that may have inhibitory effects on the repair of potentially lethal damage caused by radiation using an in vivo murine fibrosarcoma (Meth‐A tumor) in BALB/cBy male mice. The combined treatment of single administration of L‐alanosine (600 mg/kg) and single dose of X‐irradiation (20 Gy) on Meth‐A tumors produced 62% tumor control, while the radiation alone resulted in less than 5% tumor control. The potentiating effect by L‐alanosine was higher when the drug was administered 8 h prior to X‐irradiation. The dose modification factor of the drug is estimated to be 1.4 for Meth‐A tumor. The increased tumor control rates with combined alanosine and radiation were highly dependent upon the time and sequence of the combined treatment. The reason for reduced efficacy at treatment times of less than 8 h prior to X‐irradiations appears to be related in part to the modulation of the body temperature by L‐alanosine when combined with Ketamine, an anesthetic agent.
format Online
Article
Text
id pubmed-5917789
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59177892018-05-11 Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation Hong, Seong Su Alfieri, Alan A. Kim, Sang Hie Kim, Jae Ho Jpn J Cancer Res Article L‐Alanosine, an analog of L‐aspartie acid, was investigated as one of a series of chemical compounds that may have inhibitory effects on the repair of potentially lethal damage caused by radiation using an in vivo murine fibrosarcoma (Meth‐A tumor) in BALB/cBy male mice. The combined treatment of single administration of L‐alanosine (600 mg/kg) and single dose of X‐irradiation (20 Gy) on Meth‐A tumors produced 62% tumor control, while the radiation alone resulted in less than 5% tumor control. The potentiating effect by L‐alanosine was higher when the drug was administered 8 h prior to X‐irradiation. The dose modification factor of the drug is estimated to be 1.4 for Meth‐A tumor. The increased tumor control rates with combined alanosine and radiation were highly dependent upon the time and sequence of the combined treatment. The reason for reduced efficacy at treatment times of less than 8 h prior to X‐irradiations appears to be related in part to the modulation of the body temperature by L‐alanosine when combined with Ketamine, an anesthetic agent. Blackwell Publishing Ltd 1989-06 /pmc/articles/PMC5917789/ /pubmed/2503478 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01680.x Text en
spellingShingle Article
Hong, Seong Su
Alfieri, Alan A.
Kim, Sang Hie
Kim, Jae Ho
Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title_full Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title_fullStr Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title_full_unstemmed Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title_short Increased Tumor Control Rates in Murine Fibrosarcoma by Combined Therapy with L‐Alanosine and Radiation
title_sort increased tumor control rates in murine fibrosarcoma by combined therapy with l‐alanosine and radiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917789/
https://www.ncbi.nlm.nih.gov/pubmed/2503478
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01680.x
work_keys_str_mv AT hongseongsu increasedtumorcontrolratesinmurinefibrosarcomabycombinedtherapywithlalanosineandradiation
AT alfierialana increasedtumorcontrolratesinmurinefibrosarcomabycombinedtherapywithlalanosineandradiation
AT kimsanghie increasedtumorcontrolratesinmurinefibrosarcomabycombinedtherapywithlalanosineandradiation
AT kimjaeho increasedtumorcontrolratesinmurinefibrosarcomabycombinedtherapywithlalanosineandradiation