High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers

A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40(tax), has been developed. By this ELISA method, we have investigated the relationship between the presence of p40(tax) antibody in HTLV‐I‐infected mothers...

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Detalles Bibliográficos
Autores principales: Sawada, Takashi, Tohmatsu, Junichi, Obara, Takashi, Koide, Atsushi, Kamihira, Shimeru, Ichimaru, Michito, Kashiwagi, Seizaburo, Kajiyama, Wataru, Matsumura, Nobuyuki, Kinoshita, Kenichiro, Yano, Michitami, Yamaguchi, Kazunari, Kiyokawa, Tetsuyuki, Takatsuki, Kiyoshi, Taguchi, Hirokuni, Miyoshi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917792/
https://www.ncbi.nlm.nih.gov/pubmed/2503470
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01667.x
Descripción
Sumario:A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40(tax), has been developed. By this ELISA method, we have investigated the relationship between the presence of p40(tax) antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40(tax) antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40(tax) antibody may indicate an increased risk of vertical transmission of HTLV‐I.

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