High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers

A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40(tax), has been developed. By this ELISA method, we have investigated the relationship between the presence of p40(tax) antibody in HTLV‐I‐infected mothers...

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Autores principales: Sawada, Takashi, Tohmatsu, Junichi, Obara, Takashi, Koide, Atsushi, Kamihira, Shimeru, Ichimaru, Michito, Kashiwagi, Seizaburo, Kajiyama, Wataru, Matsumura, Nobuyuki, Kinoshita, Kenichiro, Yano, Michitami, Yamaguchi, Kazunari, Kiyokawa, Tetsuyuki, Takatsuki, Kiyoshi, Taguchi, Hirokuni, Miyoshi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917792/
https://www.ncbi.nlm.nih.gov/pubmed/2503470
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01667.x
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author Sawada, Takashi
Tohmatsu, Junichi
Obara, Takashi
Koide, Atsushi
Kamihira, Shimeru
Ichimaru, Michito
Kashiwagi, Seizaburo
Kajiyama, Wataru
Matsumura, Nobuyuki
Kinoshita, Kenichiro
Yano, Michitami
Yamaguchi, Kazunari
Kiyokawa, Tetsuyuki
Takatsuki, Kiyoshi
Taguchi, Hirokuni
Miyoshi, Isao
author_facet Sawada, Takashi
Tohmatsu, Junichi
Obara, Takashi
Koide, Atsushi
Kamihira, Shimeru
Ichimaru, Michito
Kashiwagi, Seizaburo
Kajiyama, Wataru
Matsumura, Nobuyuki
Kinoshita, Kenichiro
Yano, Michitami
Yamaguchi, Kazunari
Kiyokawa, Tetsuyuki
Takatsuki, Kiyoshi
Taguchi, Hirokuni
Miyoshi, Isao
author_sort Sawada, Takashi
collection PubMed
description A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40(tax), has been developed. By this ELISA method, we have investigated the relationship between the presence of p40(tax) antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40(tax) antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40(tax) antibody may indicate an increased risk of vertical transmission of HTLV‐I.
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spelling pubmed-59177922018-05-11 High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers Sawada, Takashi Tohmatsu, Junichi Obara, Takashi Koide, Atsushi Kamihira, Shimeru Ichimaru, Michito Kashiwagi, Seizaburo Kajiyama, Wataru Matsumura, Nobuyuki Kinoshita, Kenichiro Yano, Michitami Yamaguchi, Kazunari Kiyokawa, Tetsuyuki Takatsuki, Kiyoshi Taguchi, Hirokuni Miyoshi, Isao Jpn J Cancer Res Rapid Communication A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40(tax), has been developed. By this ELISA method, we have investigated the relationship between the presence of p40(tax) antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40(tax) antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40(tax) antibody may indicate an increased risk of vertical transmission of HTLV‐I. Blackwell Publishing Ltd 1989-06 /pmc/articles/PMC5917792/ /pubmed/2503470 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01667.x Text en
spellingShingle Rapid Communication
Sawada, Takashi
Tohmatsu, Junichi
Obara, Takashi
Koide, Atsushi
Kamihira, Shimeru
Ichimaru, Michito
Kashiwagi, Seizaburo
Kajiyama, Wataru
Matsumura, Nobuyuki
Kinoshita, Kenichiro
Yano, Michitami
Yamaguchi, Kazunari
Kiyokawa, Tetsuyuki
Takatsuki, Kiyoshi
Taguchi, Hirokuni
Miyoshi, Isao
High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title_full High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title_fullStr High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title_full_unstemmed High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title_short High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40(tax) Antibody‐positive Mothers
title_sort high risk of mother‐to‐child transmission of htlv‐i in p40(tax) antibody‐positive mothers
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917792/
https://www.ncbi.nlm.nih.gov/pubmed/2503470
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01667.x
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