Inhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum

(—)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two‐stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duoden...

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Detalles Bibliográficos
Autores principales: Fujita, Yoshihiro, Yamane, Tetsuro, Tanaka, Masumi, Kuwata, Katsuya, Okuzumi, Junichi, Takahashi, Toshio, Fujiki, Hirota, Okuda, Takuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917795/
https://www.ncbi.nlm.nih.gov/pubmed/2503469
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01666.x
Descripción
Sumario:(—)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two‐stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N‐ethyl‐N′‐nitro‐N‐nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

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