The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

To examine the transforming potential of the × gene product of hepatitis B virus (HBV), the X‐gene‐containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X‐coding mRNA at a different level. A positive correlation was found betwe...

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Autores principales: Shirakata, Yumiko, Kawada, Minako, Fujiki, Yukio, Sano, Haruhiko, Oda, Munehiro, Yaginuma, Katsuyuki, Kobayashi, Midori, Koike, Katsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917810/
https://www.ncbi.nlm.nih.gov/pubmed/2507484
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01686.x
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author Shirakata, Yumiko
Kawada, Minako
Fujiki, Yukio
Sano, Haruhiko
Oda, Munehiro
Yaginuma, Katsuyuki
Kobayashi, Midori
Koike, Katsuro
author_facet Shirakata, Yumiko
Kawada, Minako
Fujiki, Yukio
Sano, Haruhiko
Oda, Munehiro
Yaginuma, Katsuyuki
Kobayashi, Midori
Koike, Katsuro
author_sort Shirakata, Yumiko
collection PubMed
description To examine the transforming potential of the × gene product of hepatitis B virus (HBV), the X‐gene‐containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X‐coding mRNA at a different level. A positive correlation was found between the level of X‐coding mRNA and the saturation density of the cells. The HBx‐transformed cell lines exhibited × protein production and tumor formation in nude mice. The function of HBV in oncogenesis may involve the continuous expression of the X‐gene‐coded product in the HBV DNA‐integrated cells.
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spelling pubmed-59178102018-05-11 The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells Shirakata, Yumiko Kawada, Minako Fujiki, Yukio Sano, Haruhiko Oda, Munehiro Yaginuma, Katsuyuki Kobayashi, Midori Koike, Katsuro Jpn J Cancer Res Article To examine the transforming potential of the × gene product of hepatitis B virus (HBV), the X‐gene‐containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X‐coding mRNA at a different level. A positive correlation was found between the level of X‐coding mRNA and the saturation density of the cells. The HBx‐transformed cell lines exhibited × protein production and tumor formation in nude mice. The function of HBV in oncogenesis may involve the continuous expression of the X‐gene‐coded product in the HBV DNA‐integrated cells. Blackwell Publishing Ltd 1989-07 /pmc/articles/PMC5917810/ /pubmed/2507484 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01686.x Text en
spellingShingle Article
Shirakata, Yumiko
Kawada, Minako
Fujiki, Yukio
Sano, Haruhiko
Oda, Munehiro
Yaginuma, Katsuyuki
Kobayashi, Midori
Koike, Katsuro
The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title_full The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title_fullStr The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title_full_unstemmed The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title_short The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells
title_sort × gene of hepatitis b virus induced growth stimulation and tumorigenic transformation of mouse nih3t3 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917810/
https://www.ncbi.nlm.nih.gov/pubmed/2507484
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01686.x
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