Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma

Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of a...

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Detalles Bibliográficos
Autores principales: Shimakage, Misuzu, Chatani, Masashi, Ikegami, Nobuko, Hirai, Kanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917820/
https://www.ncbi.nlm.nih.gov/pubmed/2551868
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01685.x
Descripción
Sumario:Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single‐sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV‐infected cell.

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