Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma

Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of a...

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Detalles Bibliográficos
Autores principales: Shimakage, Misuzu, Chatani, Masashi, Ikegami, Nobuko, Hirai, Kanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917820/
https://www.ncbi.nlm.nih.gov/pubmed/2551868
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01685.x
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author Shimakage, Misuzu
Chatani, Masashi
Ikegami, Nobuko
Hirai, Kanji
author_facet Shimakage, Misuzu
Chatani, Masashi
Ikegami, Nobuko
Hirai, Kanji
author_sort Shimakage, Misuzu
collection PubMed
description Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single‐sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV‐infected cell.
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spelling pubmed-59178202018-05-11 Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma Shimakage, Misuzu Chatani, Masashi Ikegami, Nobuko Hirai, Kanji Jpn J Cancer Res Rapid Communication Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single‐sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV‐infected cell. Blackwell Publishing Ltd 1989-07 /pmc/articles/PMC5917820/ /pubmed/2551868 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01685.x Text en
spellingShingle Rapid Communication
Shimakage, Misuzu
Chatani, Masashi
Ikegami, Nobuko
Hirai, Kanji
Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title_full Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title_fullStr Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title_full_unstemmed Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title_short Rearranged Epstein‐Barr Virus Genomes and Clonal Origin in Nasopharyngeal Carcinoma
title_sort rearranged epstein‐barr virus genomes and clonal origin in nasopharyngeal carcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917820/
https://www.ncbi.nlm.nih.gov/pubmed/2551868
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01685.x
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AT hiraikanji rearrangedepsteinbarrvirusgenomesandclonalorigininnasopharyngealcarcinoma

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